Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat. No.	Product name	CAS No.	Purity
T13336	VTP50469	2169916-18-9	98.31%
T13336	VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T6173	BI 2536	755038-02-9	98.31%
T6173	BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
T23115	OXF BD 02	1429129-68-9	98.25%
T23115	OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.
T2072	BET bromodomain inhibitor	1505453-59-7	98.22%
T2072	BET bromodomain inhibitor is a potent BET inhibitor.
T4697	ABBV-744	2138861-99-9	98.2%
T4697	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T1843	XMD8-92	1234480-50-2	98.19%
T1843	XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
T6859	I-BRD9	1714146-59-4	98.16%
T6859	I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T17350	ACBI1	2375564-55-7	98.15%
T17350	ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
T2480	Apabetalone	1044870-39-4	98.08%
T2480	Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disea...
T3986	SF2523	1174428-47-7	98.06%
T3986	SF2523 is a highly selective and potent inhibitor.
T72058L	CDD-1102 HCl		98.05%
T72058L	CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.
T19618	(R)-(-)-JQ1 Enantiomer	1268524-71-5	98.03%
T19618	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
T22345	INCB054329	1628607-64-6	98.03%
T22345	INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BR...
T7264	CBP/EP300-IN-1	2443789-32-8	98%
T7264	CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
T14510	BAY-850	2099142-76-2	98%
T14510	BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasi...
T7297	KG-501	18228-17-6	98%
T7297	KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
T1973	PFI-4	900305-37-5	98%
T1973	PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T2127	OF-1	919973-83-4	98%
T2127	OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T7863	Hexamethylene bisacetamide	3073-59-4	98%
T7863	Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
T5442	A1874	2064292-12-0	98%
T5442	A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.