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Endogenous Metabolite

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as sex, age, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78476 Hydroxocobalamin 13422-51-0 98%
Hydroxocobalamin
Hydroxocobalamin (Vitamin B12a) is a naturally occurring, injectable form of vitamin B12 used as a dietary supplement to treat B12 deficiency, including pernicio...
T78485 D-Glucosamine 6-phosphate 3616-42-0 98%
D-Glucosamine 6-phosphate
D-Glucosamine 6-phosphate, an endogenous metabolite produced by glutamine fructose-6-phosphate amidotransferase (GFAT), is utilized in studies related to diabete...
T78509 Pyridoxal 66-72-8 98%
Pyridoxal
Pyridoxal represents an active form of vitamin B6 [1].
T78573 Glucocerebrosidase 37228-64-1 98%
Glucocerebrosidase
Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose ...
T78580 Erythronic acid 13752-84-6 98%
Erythronic acid
Erythronic acid, an endogenous carbohydrate metabolite, is instrumental for research into metabolism-associated disorders. It significantly influences both the d...
T78617 N-Acetylserine 16354-58-8 98%
N-Acetylserine
N-Acetylserine (N-Acetyl-L-serine) serves as the physiological inducer of cysteine biosynthesis by binding to the CysB apoprotein and stimulating cysJIH transcri...
T79357 PF-07238025 98%
PF-07238025
PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit...
T79358 PF-07247685 98%
PF-07247685
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. ...
T79459 17β-HSD10-IN-2 2316765-79-2 98%
17β-HSD10-IN-2
17β-HSD10-IN-2 (compound 11), a benzothiazolylurea-based inhibitor, specifically targets 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), avoiding mitochond...
T79755 PF-07208254 2573122-40-2 98%
PF-07208254
PF-07208254, a potent BDK inhibitor, enhances cardiometabolic endpoints in mice [1].
T79919 S-Adenosyl-L-methionine (1,4-butanedisulfonate) 200393-05-1 98%
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significan...
T80020 UDP-3-O-acyl-GlcNAc diammonium 98%
UDP-3-O-acyl-GlcNAc diammonium
UDP-3-O-acyl-GlcNAc diammonium serves as a metabolite in E. coli, playing a critical role in the biosynthesis pathway of 3-deoxy-D-manno-octulosonate (KDO) [1].
T80051 Amidase 9012-56-0 98%
Amidase
Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia. These enzymes feature a conserved AS sequence o...
T80059 Complement factor I 80295-66-5 98%
Complement factor I
Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H...
T80060 Pyruvate carboxylase 9014-19-1 98%
Pyruvate carboxylase
Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP. This enzyme i...
T80082 Hepcidin-25 (human) (acetate) 2222618-29-1 98%
Hepcidin-25 (human) (acetate)
Hepcidin-25 (human) acetate is a modulator of iron metabolism that demonstrates anti-inflammatory and antibacterial effects through the modulation of iron-mediat...
T80113 Bz-Ala-Arg 71448-11-8 98%
Bz-Ala-Arg
Bz-Ala-Arg, a dipeptide, serves as a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) for human pancreatic carboxypeptidase B and plasma carboxypep...
T80114 FA-Ala-Arg 76079-06-6 98%
FA-Ala-Arg
FA-Ala-Arg is a dipeptide featuring a furylacryloyl group that degrades to yield arginine. It augments nitric oxide (NO) synthesis in MCF-7 cells through a mecha...
T80191 His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA 98%
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, a growth hormone releasing peptide and metabolite of GHRP-1 (Ala-His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2), stimulates grow...
T80592 Ledelabricin alfa 98%
Ledelabricin alfa
Ledelabricin alfa, an isoform A variant of human proteoglycan 4 (PRG4), functions as a lubricant for joints and boundaries. It is utilized in the study of arthro...
Hydroxocobalamin
T78476
Hydroxocobalamin (Vitamin B12a) is a naturally occurring, injectable form of vitamin B12 used as a dietary supplement to treat B12 deficiency, including pernicio...
D-Glucosamine 6-phosphate
T78485
D-Glucosamine 6-phosphate, an endogenous metabolite produced by glutamine fructose-6-phosphate amidotransferase (GFAT), is utilized in studies related to diabete...
Pyridoxal
T78509
Pyridoxal represents an active form of vitamin B6 [1].
Glucocerebrosidase
T78573
Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose ...
Erythronic acid
T78580
Erythronic acid, an endogenous carbohydrate metabolite, is instrumental for research into metabolism-associated disorders. It significantly influences both the d...
N-Acetylserine
T78617
N-Acetylserine (N-Acetyl-L-serine) serves as the physiological inducer of cysteine biosynthesis by binding to the CysB apoprotein and stimulating cysJIH transcri...
PF-07238025
T79357
PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit...
PF-07247685
T79358
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. ...
17β-HSD10-IN-2
T79459
17β-HSD10-IN-2 (compound 11), a benzothiazolylurea-based inhibitor, specifically targets 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), avoiding mitochond...
PF-07208254
T79755
PF-07208254, a potent BDK inhibitor, enhances cardiometabolic endpoints in mice [1].
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
T79919
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significan...
UDP-3-O-acyl-GlcNAc diammonium
T80020
UDP-3-O-acyl-GlcNAc diammonium serves as a metabolite in E. coli, playing a critical role in the biosynthesis pathway of 3-deoxy-D-manno-octulosonate (KDO) [1].
Amidase
T80051
Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia. These enzymes feature a conserved AS sequence o...
Complement factor I
T80059
Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H...
Pyruvate carboxylase
T80060
Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP. This enzyme i...
Hepcidin-25 (human) (acetate)
T80082
Hepcidin-25 (human) acetate is a modulator of iron metabolism that demonstrates anti-inflammatory and antibacterial effects through the modulation of iron-mediat...
Bz-Ala-Arg
T80113
Bz-Ala-Arg, a dipeptide, serves as a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) for human pancreatic carboxypeptidase B and plasma carboxypep...
FA-Ala-Arg
T80114
FA-Ala-Arg is a dipeptide featuring a furylacryloyl group that degrades to yield arginine. It augments nitric oxide (NO) synthesis in MCF-7 cells through a mecha...
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA
T80191
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, a growth hormone releasing peptide and metabolite of GHRP-1 (Ala-His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2), stimulates grow...
Ledelabricin alfa
T80592
Ledelabricin alfa, an isoform A variant of human proteoglycan 4 (PRG4), functions as a lubricant for joints and boundaries. It is utilized in the study of arthro...
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TargetMol