T6818 |
DEL-22379
|
181223-80-3
|
100%
|
|
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM.
|
T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
T1144 |
Lidocaine hydrochloride
|
73-78-9
|
100%
|
|
Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and...
|
T2356 |
Ro-3306
|
872573-93-8
|
|
|
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
|
T0468 |
Lidocaine
|
137-58-6
|
98%
|
|
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation o...
|
T77731 |
ERK5-IN-6
|
2734916-64-2
|
98%
|
|
ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in...
|
T77734 |
ERK5-IN-5
|
2318792-30-0
|
98%
|
|
ERK5-IN-5 is a potent extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity and potential anticonvulsant activity that inhibits A549 ...
|
T6S0525 |
Farrerol
|
24211-30-1
|
98%
|
|
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
|
T3S2344 |
β,β-Dimethylacrylshikonin
|
24502-79-2
|
98%
|
|
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of D...
|
T60777 |
EM127
|
1886879-71-5
|
98%
|
|
EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional re...
|
TN1560 |
Dehydroeffusol
|
137319-34-7
|
98%
|
|
Dehydroeffusol (Dehydro Effusol) possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity...
|
T3857 |
Magnolin
|
31008-18-1
|
98%
|
|
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory a...
|
T36674 |
DMU-212
|
134029-62-2
|
98%
|
|
DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic...
|
T76796 |
Patritumab
|
1262787-83-6
|
98%
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
|
T12069 |
MK-8353
|
1184173-73-6
|
98%
|
|
MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)
|
T4444 |
A-674563 HCl (552325-73-2(free base))
|
2070009-66-2
|
98%
|
|
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
|
T1933 |
NVP 231
|
362003-83-6
|
98%
|
|
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
|
T5358 |
Longdaysin
|
1353867-91-0
|
98%
|
|
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).
|
T9141 |
ERK-IN-3
|
2055597-12-9
|
98%
|
|
ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the resea...
|
T5S0168 |
Atractylenolide II
|
73069-14-4
|
98%
|
|
1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p...
|