ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product name	CAS No.	Purity
T6218	Selumetinib	606143-52-6	98.73%
T6218	Selumetinib (AZD6244) (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).
T4092	AG126	118409-62-4	98.72%
T4092	AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
T6083	AZD8330	869357-68-6	98.72%
T6083	AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
T61122	ZINC12409120	1010888-06-8	98.69%
T61122	ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:...
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T77731	ERK5-IN-6	2734916-64-2	98.59%
T77731	ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in...
T2623	PD98059	167869-21-8	98.52%
T2623	PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhi...
T27242	EF24	342808-40-6	98.47%
T27242	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of M...
T3714	SUN11602	704869-38-5	98.43%
T3714	SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
T11224	Rineterkib	1715025-32-3	98.4%
T11224	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
T14547	JWG-071	2250323-50-1	98.33%
T14547	JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD...
T4496	LM22B-10	342777-54-2	98.19%
T4496	LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
T1843	XMD8-92	1234480-50-2	98.19%
T1843	XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
TN1490	Chrysoeriol	491-71-4	98.16%
TN1490	Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
T2532	Tauroursodeoxycholate	14605-22-2	98.12%
T2532	Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. T...
T10809L	CHPG hydrochloride	T10809L	98.1%
T10809L	CHPG hydrochloride is a selective agonist of mGluR5.
TN2316	Xanthyletin	553-19-5	98.09%
TN2316	Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.
TN2166	Rupestonic acid	115473-63-7	98.07%
TN2166	Rupestonic acid is a compound in Artemisia rupestris L., a well-known traditional Uighur medicine for the treatment of colds. Rupestonic acid has an anti-influen...
T6066	SCH772984	942183-80-4	98.01%
T6066	SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.
TMS2181	Trans-Zeatin	1637-39-4	98%
TMS2181	trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processin...