T2973 |
Astragaloside IV
|
84687-43-4
|
98.85%
|
|
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metall...
|
TN2179 |
Saponarin
|
20310-89-8
|
98.84%
|
|
Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
|
T10827 |
CK2/ERK8-IN-1
|
1085822-09-8
|
98.82%
|
|
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
|
TN1459 |
Bufarenogin
|
17008-65-0
|
98.77%
|
|
Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad P...
|
T72662 |
NMDAR/TRPM4-IN-2
|
2243506-33-2
|
98.77%
|
|
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
|
T6511 |
Ravoxertinib
|
1453848-26-4
|
98.76%
|
|
Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).
|
T4092 |
AG126
|
118409-62-4
|
98.72%
|
|
AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
|
T6083 |
AZD8330
|
869357-68-6
|
98.72%
|
|
AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
|
T61122 |
ZINC12409120
|
1010888-06-8
|
98.69%
|
|
ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:...
|
T6677 |
Sophocarpine
|
6483-15-4
|
98.67%
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
T2356 |
Ro-3306
|
872573-93-8
|
98.59%
|
|
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
|
T2623 |
PD98059
|
167869-21-8
|
98.52%
|
|
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhi...
|
T27242 |
EF24
|
342808-40-6
|
98.47%
|
|
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of M...
|
T3714 |
SUN11602
|
704869-38-5
|
98.43%
|
|
SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
|
T11224 |
Rineterkib
|
1715025-32-3
|
98.4%
|
|
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
|
T0468 |
Lidocaine
|
137-58-6
|
98.35%
|
|
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation o...
|
T14547 |
JWG-071
|
2250323-50-1
|
98.33%
|
|
JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD...
|
TN2346 |
Mogrol
|
88930-15-8
|
98.21%
|
|
Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
|
T4496 |
LM22B-10
|
342777-54-2
|
98.19%
|
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
|
T1843 |
XMD8-92
|
1234480-50-2
|
98.19%
|
|
XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
|