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ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN5100 Taspine 602-07-3 98%
Taspine
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN3397 Alpinumisoflavone 34086-50-5 98%
Alpinumisoflavone
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
T12409 PERK-IN-2 1337531-83-5 98%
PERK-IN-2
PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).
TN1793 Isorhamnetin 3-O-galactoside 6743-92-6 98%
Isorhamnetin 3-O-galactoside
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN4489 Manassantin A 88497-87-4 98%
Manassantin A
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN3539 Broussonin A 73731-87-0 98%
Broussonin A
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3839 Desoxo-narchinol A 53859-06-6 98%
Desoxo-narchinol A
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN2995 4,10-Aromadendranediol 70051-38-6 98%
4,10-Aromadendranediol
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 189689-32-5 98%
6,4'-Dihydroxy-7-methoxyflavanone
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
TN3152 6-Acetonyldihydrochelerythrine 22864-92-2 98%
6-Acetonyldihydrochelerythrine
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN4490 Manassantin B 88497-88-5 98%
Manassantin B
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
T16998 Tauroursodeoxycholate dihydrate 117609-50-4 98%
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
TN4213 Hirsutenone 41137-87-5 98%
Hirsutenone
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 57719-81-0 98%
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
T13680 Enniatin B1 19914-20-6 98%
Enniatin B1
Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier, decreases the activation of ERK (p44/p42), and inhibits moderately TNF-α-induced NF-κB activa...
T12410 PERK-IN-3 1337532-08-7 98%
PERK-IN-3
PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).
T23337 SCH772984 HCl T23337 98%
SCH772984 HCl
SCH772984 HCl is a selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors, with IC50s of 4 and 1 nM, respectively. SC...
T36067 Bongkrekic acid 11076-19-0 98%
Bongkrekic acid
Bongkrekic acid (Bongkrekic Acid (ammonium salt)) is a mitochondrial toxin secreted by Burkholderia gladioli that inhibits adenine nucleotide translocase (ANT).B...
TN5387 Grasshopper ketone 41703-38-2 98%
Grasshopper ketone
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...
TN3003 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol 69768-97-4 98%
4-(3,4-Dimethoxyphenyl)-3-buten-1-ol
(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...
Taspine
TN5100
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
Alpinumisoflavone
TN3397
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
PERK-IN-2
T12409
PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).
Isorhamnetin 3-O-galactoside
TN1793
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
Broussonin A
TN3539
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
Desoxo-narchinol A
TN3839
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
4,10-Aromadendranediol
TN2995
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
6-Acetonyldihydrochelerythrine
TN3152
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
Manassantin B
TN4490
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
Tauroursodeoxycholate dihydrate
T16998
Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
Hirsutenone
TN4213
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
Enniatin B1
T13680
Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier, decreases the activation of ERK (p44/p42), and inhibits moderately TNF-α-induced NF-κB activa...
PERK-IN-3
T12410
PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).
SCH772984 HCl
T23337
SCH772984 HCl is a selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors, with IC50s of 4 and 1 nM, respectively. SC...
Bongkrekic acid
T36067
Bongkrekic acid (Bongkrekic Acid (ammonium salt)) is a mitochondrial toxin secreted by Burkholderia gladioli that inhibits adenine nucleotide translocase (ANT).B...
Grasshopper ketone
TN5387
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...
4-(3,4-Dimethoxyphenyl)-3-buten-1-ol
TN3003
(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...
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TargetMol