EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T6136	Canertinib	267243-28-7	99.18%
T6136	Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment sig...
T6039	TAK-285	871026-44-7	99.17%
T6039	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Auro...
T5410	PD158780	171179-06-9	99.16%
T5410	PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR, ErbB2, ErbB3, and ErbB4 (IC50s: 8μM, 49 n...
T9754	BLU-945	2660250-10-0	99.16%
T9754	BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR wi...
T5168	EGFR-IN-12	879127-07-8	99.15%
T5168	EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
T6932	PD168393	194423-15-9	99.13%
T6932	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T7649	Tyrphostin A1	2826-26-8	99.13%
T7649	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .
T22396	PF-6274484	1035638-91-5	99.12%
T22396	PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells ...
T3108	CUDC-101	1012054-59-9	99.12%
T3108	CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.
T6427	Butein	487-52-5	99.11%
T6427	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB ...
T14336	Allitinib	897383-62-9	99.10%
T14336	Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
T6712	Tyrphostin AG 879	148741-30-4	99.05%
T6712	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
T36715	Tetrac	67-30-1	99.04%
T36715	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGF...
T6619	Desmethyl Erlotinib hydrochloride	183320-51-6	99.03%
T6619	Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM...
T2047	AG-1478	153436-53-4	99.03%
T2047	AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T8751	AZD8931 diFuMaric acid	1196531-39-1	99%
T8751	AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).
T3402	20(S)-Ginsenoside Rg3	14197-60-5	98.99%
T3402	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
T22974	Methyl 2,5-dihydroxycinnamate	63177-57-1	98.98%
T22974	EGF receptor-associated tyrosine kinases inhibitor
T4694	AG-1557 hydrochloride (189290-58-2(free base))	T4694	98.95%
T4694	AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
T6733	WZ-3146	1214265-56-1	98.95%
T6733	WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I)...