T15621 |
Rilematovir
|
1383450-81-4
|
99.82%
|
|
Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncyt...
|
T2851 |
Daphnetin
|
486-35-1
|
99.82%
|
|
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), an...
|
T2280 |
Endoxifen (Z-isomer)
|
112093-28-4
|
99.81%
|
|
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
|
T7175 |
Alflutinib mesylate
|
2130958-55-1
|
99.81%
|
|
Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
|
T11157L |
EGFR-IN-1 hydrochloride
|
2227455-78-7
|
99.8%
|
|
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochlori...
|
T2307 |
Icotinib Hydrochloride
|
1204313-51-8
|
99.77%
|
|
Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineopla...
|
T3721 |
Avitinib maleate
|
1557268-88-8
|
99.77%
|
|
Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
|
T4528 |
Tyrphostin AG 528
|
133550-49-9
|
99.74%
|
|
Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
|
T6824 |
EAI045
|
1942114-09-1
|
99.73%
|
|
EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.
|
T16162 |
Mutated EGFR-IN-1
|
1421372-66-8
|
99.73%
|
|
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant...
|
T2446 |
KI8751
|
228559-41-9
|
99.73%
|
|
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
|
T8151 |
Mobocertinib
|
1847461-43-1
|
99.72%
|
|
Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent
|
T6235 |
Lapatinib Ditosylate
|
388082-77-7
|
99.71%
|
|
Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
|
T35916 |
Simotinib
|
944258-89-3
|
99.7%
|
|
Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell ...
|
T9304 |
(S)-Sunvozertinib
|
2370013-49-1
|
99.69%
|
|
(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
|
T8758 |
Poziotinib hydrochloride
|
1429757-68-5
|
99.69%
|
|
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells ...
|
T5155 |
(E)-AG 99
|
122520-85-8
|
99.67%
|
|
(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
|
T1773 |
Afatinib Dimaleate
|
850140-73-7
|
99.66%
|
|
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth f...
|
T67385 |
Neratinib maleate
|
915942-22-2
|
99.64%
|
|
Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respec...
|
T11161 |
EGFR-IN-7
|
2267329-76-8
|
99.64%
|
|
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
|