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EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15621 Rilematovir 1383450-81-4 99.82%
Rilematovir
Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncyt...
T2851 Daphnetin 486-35-1 99.82%
Daphnetin
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), an...
T2280 Endoxifen (Z-isomer) 112093-28-4 99.81%
Endoxifen (Z-isomer)
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
T7175 Alflutinib mesylate 2130958-55-1 99.81%
Alflutinib mesylate
Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
T11157L EGFR-IN-1 hydrochloride 2227455-78-7 99.8%
EGFR-IN-1 hydrochloride
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochlori...
T2307 Icotinib Hydrochloride 1204313-51-8 99.77%
Icotinib Hydrochloride
Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineopla...
T3721 Avitinib maleate 1557268-88-8 99.77%
Avitinib maleate
Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
T4528 Tyrphostin AG 528 133550-49-9 99.74%
Tyrphostin AG 528
Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
T6824 EAI045 1942114-09-1 99.73%
EAI045
EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.
T16162 Mutated EGFR-IN-1 1421372-66-8 99.73%
Mutated EGFR-IN-1
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant...
T2446 KI8751 228559-41-9 99.73%
KI8751
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T8151 Mobocertinib 1847461-43-1 99.72%
Mobocertinib
Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent
T6235 Lapatinib Ditosylate 388082-77-7 99.71%
Lapatinib Ditosylate
Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
T35916 Simotinib 944258-89-3 99.7%
Simotinib
Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell ...
T9304 (S)-Sunvozertinib 2370013-49-1 99.69%
(S)-Sunvozertinib
(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
T8758 Poziotinib hydrochloride 1429757-68-5 99.69%
Poziotinib hydrochloride
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells ...
T5155 (E)-AG 99 122520-85-8 99.67%
(E)-AG 99
(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
T1773 Afatinib Dimaleate 850140-73-7 99.66%
Afatinib Dimaleate
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth f...
T67385 Neratinib maleate 915942-22-2 99.64%
Neratinib maleate
Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respec...
T11161 EGFR-IN-7 2267329-76-8 99.64%
EGFR-IN-7
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
Rilematovir
T15621
Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncyt...
Daphnetin
T2851
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), an...
Endoxifen (Z-isomer)
T2280
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
Alflutinib mesylate
T7175
Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
EGFR-IN-1 hydrochloride
T11157L
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochlori...
Icotinib Hydrochloride
T2307
Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineopla...
Avitinib maleate
T3721
Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
Tyrphostin AG 528
T4528
Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
EAI045
T6824
EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.
Mutated EGFR-IN-1
T16162
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant...
KI8751
T2446
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
Mobocertinib
T8151
Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent
Lapatinib Ditosylate
T6235
Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
Simotinib
T35916
Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell ...
(S)-Sunvozertinib
T9304
(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
Poziotinib hydrochloride
T8758
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells ...
(E)-AG 99
T5155
(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
Afatinib Dimaleate
T1773
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth f...
Neratinib maleate
T67385
Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respec...
EGFR-IN-7
T11161
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
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