EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T22296	Cisapride hydrate	260779-88-2	98%
T22296	Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
T4485	Lazertinib	1903008-80-9	99.96%
T4485	Lazertinib (GNS-1480) is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790...
T2303	(S)-Afatinib	439081-18-2	99.96%
T2303	(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, r...
T2364	Tucatinib	937263-43-9	99.96%
T2364	Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
T19814	CP-380736	179688-29-0	99.91%
T19814	CP-380736 (PF-00520893) is an epidermal growth factor receptor (EGFR) inhibitor. EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an ...
T1144L	Lidocaine Hydrochloride hydrate	6108-05-0	99.91%
T1144L	Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
T2491	AZ-5104	1421373-98-9	99.9%
T2491	AZ5104 is a potent EGFR inhibitor.
T0373	Erlotinib	183321-74-6	99.89%
T0373	Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.
T22954	LY 456236 hydrochloride	338736-46-2	99.89%
T22954	LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activ...
T3558	EBE-A22	229476-53-3	99.88%
T3558	EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.
T6124	Mubritinib	366017-09-6	99.87%
T6124	Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.
T2894	Norcantharidin	5442-12-6	99.86%
T2894	Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
T10419	AV-412	451493-31-5	99.85%
T10419	AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).
T13619	Cloperastine fendizoate	85187-37-7	99.85%
T13619	Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
T34656	SKLB 1028	1350544-93-2	99.85%
T34656	SKLB 1028 (Ruserontinib) is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. SKLB 1028 shows excellent activity in FLT3-driven AML models and con...
T5462	Almonertinib	1899921-05-1	99.85%
T5462	Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.
T6908	NSC 228155	113104-25-9	99.84%
T6908	NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T2106	WS6	1421227-53-3	99.83%
T2106	WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T6196	PP1	172889-26-8	99.82%
T6196	PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
T15621	Rilematovir	1383450-81-4	99.82%
T15621	Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncyt...