Home Tools
Log in
Cart

E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4036 Solasodine 126-17-0 99.64%
Solasodine
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cyt...
T16901 SMIP004 143360-00-3 99.63%
SMIP004
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
T6149 YH239-EE 1364488-67-4 99.61%
YH239-EE
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T3110 PRT4165 31083-55-3 99.6%
PRT4165
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T72043 SCFSkp2-IN-2 1375060-02-8 99.28%
SCFSkp2-IN-2
SCFSkp2-IN-2 is a Skp2 inhibitor with a K D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .
T24136 Heclin 890605-54-6 99.25%
Heclin
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
T6332 Pevonedistat 905579-51-3 99.2%
Pevonedistat
Pevonedistat (MLN4924) is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
T8564 BC-1382 1013753-99-5 99.15%
BC-1382
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
T8929 BC1618 2222094-18-8 99.09%
BC1618
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signali...
T3549 Avadomide 1015474-32-4 99.07%
Avadomide
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
T6254 Idasanutlin 1229705-06-9 99.01%
Idasanutlin
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T63790 Cbl-b-IN-3 2573775-59-2 98.99%
Cbl-b-IN-3
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in...
TQ0231 NVP-CGM097 1313363-54-0 98.92%
NVP-CGM097
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
T3517 RO8994 1309684-94-3 98.87%
RO8994
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
TQ0127 Navtemadlin 1352066-68-2 98.86%
Navtemadlin
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T6614 Nutlin-3b 675576-97-3 98.83%
Nutlin-3b
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-...
T13349 WS-383 2247544-02-9 98.8%
WS-383
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
T28124 N106 862974-25-2 98.75%
N106
N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
T6023 Nutlin-3a 675576-98-4 98.73%
Nutlin-3a
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
T8816 NAE-IN-M22 864420-54-2 98.67%
NAE-IN-M22
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines...
Solasodine
T4036
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cyt...
SMIP004
T16901
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
YH239-EE
T6149
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
PRT4165
T3110
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
SCFSkp2-IN-2
T72043
SCFSkp2-IN-2 is a Skp2 inhibitor with a K D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .
Heclin
T24136
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
Pevonedistat
T6332
Pevonedistat (MLN4924) is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
BC-1382
T8564
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
BC1618
T8929
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signali...
Avadomide
T3549
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
Idasanutlin
T6254
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
Cbl-b-IN-3
T63790
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in...
NVP-CGM097
TQ0231
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
RO8994
T3517
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
Navtemadlin
TQ0127
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
Nutlin-3b
T6614
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-...
WS-383
T13349
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
N106
T28124
N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
Nutlin-3a
T6023
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
NAE-IN-M22
T8816
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines...
1 2 3 4
TargetMol