T4036 |
Solasodine
|
126-17-0
|
99.64%
|
|
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cyt...
|
T16901 |
SMIP004
|
143360-00-3
|
99.63%
|
|
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
|
T6149 |
YH239-EE
|
1364488-67-4
|
99.61%
|
|
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
|
T3110 |
PRT4165
|
31083-55-3
|
99.6%
|
|
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
|
T72043 |
SCFSkp2-IN-2
|
1375060-02-8
|
99.28%
|
|
SCFSkp2-IN-2 is a Skp2 inhibitor with a K D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .
|
T24136 |
Heclin
|
890605-54-6
|
99.25%
|
|
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
|
T6332 |
Pevonedistat
|
905579-51-3
|
99.2%
|
|
Pevonedistat (MLN4924) is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
|
T8564 |
BC-1382
|
1013753-99-5
|
99.15%
|
|
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
|
T8929 |
BC1618
|
2222094-18-8
|
99.09%
|
|
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signali...
|
T3549 |
Avadomide
|
1015474-32-4
|
99.07%
|
|
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
|
T6254 |
Idasanutlin
|
1229705-06-9
|
99.01%
|
|
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
|
T63790 |
Cbl-b-IN-3
|
2573775-59-2
|
98.99%
|
|
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in...
|
TQ0231 |
NVP-CGM097
|
1313363-54-0
|
98.92%
|
|
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
|
T3517 |
RO8994
|
1309684-94-3
|
98.87%
|
|
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
|
TQ0127 |
Navtemadlin
|
1352066-68-2
|
98.86%
|
|
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
|
T6614 |
Nutlin-3b
|
675576-97-3
|
98.83%
|
|
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-...
|
T13349 |
WS-383
|
2247544-02-9
|
98.8%
|
|
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
|
T28124 |
N106
|
862974-25-2
|
98.75%
|
|
N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
|
T6023 |
Nutlin-3a
|
675576-98-4
|
98.73%
|
|
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
|
T8816 |
NAE-IN-M22
|
864420-54-2
|
98.67%
|
|
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines...
|