DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T4641	Branaplam	1562338-42-4	99.4%
T4641	Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
T22980	MIRA-1	72835-26-8	99.38%
T22980	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with...
T1591	Ancitabine hydrochloride	10212-25-6	99.37%
T1591	Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabin...
T4311	HAMNO	138736-73-9	99.35%
T4311	HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).
T1679	Thiostrepton	1393-48-2	99.33%
T1679	Thiostrepton (Alaninamide) is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been u...
TNU0091	3'-Deoxy-3'-fluoroguanosine	123402-21-1	99.33%
TNU0091	3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons. 3 '-Deoxy-3' -fluoroguanosine is used to tr...
T40236	ART812	2607138-82-7	99.32%
T40236	ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediate...
T6S0139	Neobavaisoflavone	41060-15-5	99.31%
T6S0139	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. ...
T0148	Folinic acid calcium	1492-18-8	99.3%
T0148	Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T5530	Mithramycin A	18378-89-7	99.28%
T5530	Mithramycin A (Plicamycin), a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of various cancer...
T1501	Rifabutin	72559-06-9	99.27%
T1501	Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesi...
T35455	N-Nitrosodiethylamine	55-18-5	99.26%
T35455	N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in water, tobacco smoke, cheddar cheese,...
T4345	CeMMEC1	440662-09-9	99.26%
T4345	CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
T2100	CX-5461	1138549-36-6	99.25%
T2100	CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA.
T6501	Fludarabine Phosphate	75607-67-9	99.25%
T6501	Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) wi...
T15611	JH-RE-06	1361227-90-8	99.24%
T15611	JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (...
T6194	Fidaxomicin	873857-62-6	99.23%
T6194	Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal sys...
T5013	Brequinar	96187-53-0	99.21%
T5013	Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
T5017	Nimustine Hydrochloride	55661-38-6	99.2%
T5017	Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
T9121	AG-636	1623416-31-8	99.19%
T9121	AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.