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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat. No. Product name CAS No. Purity Chemical Structure
T2410 Nedaplatin 95734-82-0 98.69%
Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate i...
T4010 Juglone 481-39-0 98.73%
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl...
T4593 ISOPIMPINELLIN 482-27-9 98.74%
Antiviral, anti HIV.
T13791 2-(Methylamino)-1H-purin-6(7H)-one 10030-78-1 98.74%
2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids, is a modified nucleoside.
TN2202 Sempervirine 6882-99-1 98.81%
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
T9150 SCR130 2377858-38-1 98.9%
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- is enzyme inhibition, antiproliferative effects and antifungal activity.
TQ0184 Chebulinic acid 18942-26-2 98.91%
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T3157 COH29 1190932-38-7 98.92%
COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity...
T2504 Pritelivir 348086-71-5 98.92%
Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
TN1990 Norathyriol 3542-72-1 98.93%
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T9103 BVDV-IN-1 345651-04-9 98.93%
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVD...
TN1134 Euscaphic acid 53155-25-2 98.93%
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
T1120 Dacarbazine 4342-03-4 99%
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
T2069 TH287 1609960-30-6 99%
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T0802 Procaine hydrochloride 51-05-8 99%
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
T10936 D-I03 688342-78-1 99.04%
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC...
T12006 Metarrestin 1443414-10-5 99.04%
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts th...
T6632 Raltitrexed 112887-68-0 99.06%
Raltitrexed(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
T13174 TMPyP4 tosylate 36951-72-1 99.11%
TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
T13231L Trovafloxacin mesylate 147059-75-4 99.12%
Trovafloxacin mesylate is an effective and selective inhibitor of pannexin 1 channel (PANX1, IC50 = 4 μM). Trovafloxacin mesylate exhibits potent activity agains...
Nedaplatin
T2410
Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate i...
Juglone
T4010
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl...
ISOPIMPINELLIN
T4593
Antiviral, anti HIV.
2-(Methylamino)-1H-purin-6(7H)-one
T13791
2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids, is a modified nucleoside.
Sempervirine
TN2202
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
SCR130
T9150
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- is enzyme inhibition, antiproliferative effects and antifungal activity.
Chebulinic acid
TQ0184
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
COH29
T3157
COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity...
Pritelivir
T2504
Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
Norathyriol
TN1990
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
BVDV-IN-1
T9103
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVD...
Euscaphic acid
TN1134
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
Dacarbazine
T1120
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
TH287
T2069
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Procaine hydrochloride
T0802
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
D-I03
T10936
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC...
Metarrestin
T12006
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts th...
Raltitrexed
T6632
Raltitrexed(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
TMPyP4 tosylate
T13174
TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
Trovafloxacin mesylate
T13231L
Trovafloxacin mesylate is an effective and selective inhibitor of pannexin 1 channel (PANX1, IC50 = 4 μM). Trovafloxacin mesylate exhibits potent activity agains...
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