DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T2410	Nedaplatin	95734-82-0	98.69%
T2410	Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate i...
T4010	Juglone	481-39-0	98.73%
T4010	Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl...
T4593	ISOPIMPINELLIN	482-27-9	98.74%
T4593	Antiviral, anti HIV.
T13791	2-(Methylamino)-1H-purin-6(7H)-one	10030-78-1	98.74%
T13791	2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids, is a modified nucleoside.
TN2202	Sempervirine	6882-99-1	98.81%
TN2202	Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
T9150	SCR130	2377858-38-1	98.9%
T9150	1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- is enzyme inhibition, antiproliferative effects and antifungal activity.
TQ0184	Chebulinic acid	18942-26-2	98.91%
TQ0184	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T3157	COH29	1190932-38-7	98.92%
T3157	COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity...
T2504	Pritelivir	348086-71-5	98.92%
T2504	Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
TN1990	Norathyriol	3542-72-1	98.93%
TN1990	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T9103	BVDV-IN-1	345651-04-9	98.93%
T9103	BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVD...
TN1134	Euscaphic acid	53155-25-2	98.93%
TN1134	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
T1120	Dacarbazine	4342-03-4	99%
T1120	Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
T2069	TH287	1609960-30-6	99%
T2069	TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T0802	Procaine hydrochloride	51-05-8	99%
T0802	Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
T10936	D-I03	688342-78-1	99.04%
T10936	D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC...
T12006	Metarrestin	1443414-10-5	99.04%
T12006	Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts th...
T6632	Raltitrexed	112887-68-0	99.06%
T6632	Raltitrexed（IC50 of 9 nM）, a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
T13174	TMPyP4 tosylate	36951-72-1	99.11%
T13174	TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
T13231L	Trovafloxacin mesylate	147059-75-4	99.12%
T13231L	Trovafloxacin mesylate is an effective and selective inhibitor of pannexin 1 channel (PANX1, IC50 = 4 μM). Trovafloxacin mesylate exhibits potent activity agains...