Home Tools
Log in
Cart

DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9961 L82-G17 92285-87-5 99.78%
L82-G17
L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
T6369 Adenine hemisulfate 321-30-2 99.78%
Adenine hemisulfate
Adenine hemisulfate (Diadenine sulphate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry....
T9086 Deoxythymidine-5'-triphosphate trisodium 27821-54-1 99.77%
Deoxythymidine-5'-triphosphate trisodium
Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate (dTTP) trisodium salt) is one of the four natural deoxynucleotides. It is used for the b...
T7865 Danofloxacin 112398-08-0 99.77%
Danofloxacin
Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.
T8003 Methotrexate disodium 7413-34-5 99.77%
Methotrexate disodium
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
T27398 Gallium maltolate 108560-70-9 99.75%
Gallium maltolate
Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.
T9656 AP-1/NF-κB activation inhibitor 1 188936-12-1 99.74%
AP-1/NF-κB activation inhibitor 1
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
T7222 GS-441524 1191237-69-0 99.73%
GS-441524
GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
T6972 RS-1 312756-74-4 99.72%
RS-1
RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.
T4517 L189 64232-83-3 99.72%
L189
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
T23820 BRD32048 433694-46-3 99.69%
BRD32048
BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.
T9051 ZYN57939 1639357-93-9 99.68%
ZYN57939
ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM agai...
T15282 Filibuvir 877130-28-4 99.68%
Filibuvir
Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with E...
T14501 BAY-2402234 2225819-06-5 99.67%
BAY-2402234
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor ...
T7174 Urolithin A 1143-70-0 99.66%
Urolithin A
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T6758 Anisomycin 22862-76-6 99.66%
Anisomycin
Anisomycin (NSC-76712) is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transfera...
T1276 Danofloxacin mesylate 119478-55-6 99.66%
Danofloxacin mesylate
Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
T8873 Bractoppin 2290527-07-8 99.65%
Bractoppin
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrat...
T1272L Cytarabine hydrochloride 69-74-9 99.62%
Cytarabine hydrochloride
Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA ...
T67509 Cholesteryl Hemisuccinate 1510-21-0 99.61%
Cholesteryl Hemisuccinate
Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, antic...
L82-G17
T9961
L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
Adenine hemisulfate
T6369
Adenine hemisulfate (Diadenine sulphate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry....
Deoxythymidine-5'-triphosphate trisodium
T9086
Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate (dTTP) trisodium salt) is one of the four natural deoxynucleotides. It is used for the b...
Danofloxacin
T7865
Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.
Methotrexate disodium
T8003
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
Gallium maltolate
T27398
Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.
AP-1/NF-κB activation inhibitor 1
T9656
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
GS-441524
T7222
GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
RS-1
T6972
RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.
L189
T4517
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
BRD32048
T23820
BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.
ZYN57939
T9051
ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM agai...
Filibuvir
T15282
Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with E...
BAY-2402234
T14501
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor ...
Urolithin A
T7174
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Anisomycin
T6758
Anisomycin (NSC-76712) is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transfera...
Danofloxacin mesylate
T1276
Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
Bractoppin
T8873
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrat...
Cytarabine hydrochloride
T1272L
Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA ...
Cholesteryl Hemisuccinate
T67509
Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, antic...
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
TargetMol