DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T7429	Datelliptium chloride	105118-14-7	98%
T7429	Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.
TN4913	Riddelline	23246-96-0	98%
TN4913	Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
TN3691	Communic acid	2761-77-5	98%
TN3691	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN4227	Horminone	21887-01-4	98%
TN4227	Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
T17071	Thiarabine	26599-17-7	98%
T17071	Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.
TN1374	α-Chaconine	20562-03-2	98%
TN1374	Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Al...
TN5011	Shizukaol B	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN2529	1-Decarboxy-3-oxo-ceanothic acid	214150-74-0	98%
TN2529	1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in par...
T13479	2-Keto-D-galactose	54142-77-7	98%
T13479	2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.
TN4437	Licorisoflavan A	129314-37-0	98%
TN4437	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
T15094	Dehydroaltenusin	31186-13-7	98%
T15094	Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits ma...
T73367	Zn(BQTC)	2785342-54-1	98%
T73367	Zn(BQTC) is a potent inhibitor of both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), causing significant damage that disrupts mitochondrial and nuclear funct...
T74630	RNA polymerase II-IN-1	2891451-07-1	98%
T74630	RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicit...
T36667	2'-Deoxyadenosine-5'-triphosphate	1927-31-7	98%
T36667	2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or re...
TQ0016	NKP-1339	197723-00-5	98%
TQ0016	NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
T16749	Rifalazil	129791-92-0	98%
T16749	Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymeras...
TMA0291	Dehydroglyasperin D	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN2507	1,6,7-Trihydroxyxanthone	25577-04-2	98%
TN2507	1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell gro...
TN5153	Torilin	13018-10-5	98%
TN5153	Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...