DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T1038	Fludarabine	21679-14-1	98%
T1038	Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T1086	Vitamin D2	50-14-6	98%
T1086	Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder ...
T6357	(S)-crizotinib	1374356-45-2	98%
T6357	(S)-crizotinib（IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
T0926	Azelaic acid	123-99-9	98%
T0926	Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular p...
T2275	YK-4-279	1037184-44-3	98%
T2275	YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
T1408	Capecitabine	154361-50-9	98%
T1408	Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively ac...
T0717L	Enoxacin	74011-58-8	98%
T0717L	Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T4656	RAD51 Inhibitor B02	1290541-46-6	98%
T4656	RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
T40192	DGTP	2564-35-4	98%
T40192	dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
T12718L	RG7800	1449598-06-4	98%
T12718L	RG7800 has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.
T7222	GS-441524	1191237-69-0	98%
T7222	GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
T1558	Resveratrol	501-36-0	98%
T1558	Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T7655	Fialuridine	69123-98-4	98%
T7655	Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and...
TN1097	β-Boswellic acid	631-69-6	98%
TN1097	Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
T7747	Datelliptium chloride hydrochloride	157000-76-5	98%
T7747	Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
T2276	RI-1	415713-60-9	98%
T2276	RI-1 is a RAD51 inhibitor (IC50: 5-30 μM).
T0189L	Pemetrexed disodium	150399-23-8	98%
T0189L	Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
T0676	Hydroxyurea	127-07-1	98%
T0676	Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T1721	2'-Deoxyuridine	951-78-0	98%
T1721	2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnos...
T2201	6-Mercaptopurine hydrate	6112-76-1	98%
T2201	6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in...