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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T22195 CBFβ Inhibitor 493028-20-9 96.50%
CBFβ Inhibitor
CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.
T11600 IBR2 313526-24-8 96.15%
IBR2
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with...
T33762 Fosifloxuridine nafalbenamide 1332837-31-6 95.87%
Fosifloxuridine nafalbenamide
Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ...
TN1683 Gentisin 437-50-3 95.34%
Gentisin
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.
T7520 Deoxycytidine triphosphate 2056-98-6 95.19%
Deoxycytidine triphosphate
Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-tim...
T1454 Acyclovir 59277-89-3 100.00%
Acyclovir
Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, vari...
T38427 DUTP trisodium 102814-08-4 100.00%
dUTP trisodium
dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
T22667 CID 5951923 749872-43-3 100.00%
CID 5951923
CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.
T1506 Vidarabine 5536-17-4 100%
Vidarabine
Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum...
T1038 Fludarabine 21679-14-1 100%
Fludarabine
Fludarabine (Fludarabinum) is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T2A2537 Guanine 73-40-5 100%
Guanine
Guanine (2-Aminohypoxanthine) is a purine base that is a constituent of nucleotides occurring in nucleic acids.
T1617 Enrofloxacin 93106-60-6 100%
Enrofloxacin
Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.
T2942 Psoralen 66-97-7 100%
Psoralen
Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
T0251 Gemcitabine 95058-81-4 100%
Gemcitabine
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. G...
T8354 Triazavirin 928659-17-0 100%
Triazavirin
Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.
T1087 Valacyclovir hydrochloride 124832-27-5 100%
Valacyclovir hydrochloride
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.
T0297 Clofarabine 123318-82-1 100%
Clofarabine
Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase...
T8648 6-AZATHYMINE 932-53-6 100%
6-AZATHYMINE
6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azauracil acted as a competitive inhibitor with respect to beta-alanine,...
T5942 Docosanoic acid 112-85-6 100%
Docosanoic acid
Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.
T2708 SL327 305350-87-2 100%
SL327
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
CBFβ Inhibitor
T22195
CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.
IBR2
T11600
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with...
Fosifloxuridine nafalbenamide
T33762
Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ...
Gentisin
TN1683
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.
Deoxycytidine triphosphate
T7520
Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-tim...
Acyclovir
T1454
Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, vari...
dUTP trisodium
T38427
dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
CID 5951923
T22667
CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.
Vidarabine
T1506
Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum...
Fludarabine
T1038
Fludarabine (Fludarabinum) is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
Guanine
T2A2537
Guanine (2-Aminohypoxanthine) is a purine base that is a constituent of nucleotides occurring in nucleic acids.
Enrofloxacin
T1617
Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.
Psoralen
T2942
Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
Gemcitabine
T0251
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. G...
Triazavirin
T8354
Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.
Valacyclovir hydrochloride
T1087
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.
Clofarabine
T0297
Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase...
6-AZATHYMINE
T8648
6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azauracil acted as a competitive inhibitor with respect to beta-alanine,...
Docosanoic acid
T5942
Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.
SL327
T2708
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
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TargetMol