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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat. No. Product name CAS No. Purity Chemical Structure
T1038 Fludarabine 21679-14-1 98%
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T1086 Vitamin D2 50-14-6 98%
Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder ...
T6357 (S)-crizotinib 1374356-45-2 98%
(S)-crizotinib(IC50 of 72 nM), an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
T0926 Azelaic acid 123-99-9 98%
Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular p...
T2275 YK-4-279 1037184-44-3 98%
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
T1408 Capecitabine 154361-50-9 98%
Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively ac...
T0717L Enoxacin 74011-58-8 98%
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T4656 RAD51 Inhibitor B02 1290541-46-6 98%
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
T40192 DGTP 2564-35-4 98%
dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
T12718L RG7800 1449598-06-4 98%
RG7800 has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.
T7222 GS-441524 1191237-69-0 98%
GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
T1558 Resveratrol 501-36-0 98%
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T7655 Fialuridine 69123-98-4 98%
Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and...
TN1097 β-Boswellic acid 631-69-6 98%
Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
T7747 Datelliptium chloride hydrochloride 157000-76-5 98%
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
T2276 RI-1 415713-60-9 98%
RI-1 is a RAD51 inhibitor (IC50: 5-30 μM).
T0189L Pemetrexed disodium 150399-23-8 98%
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
T0676 Hydroxyurea 127-07-1 98%
Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T1721 2'-Deoxyuridine 951-78-0 98%
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnos...
T2201 6-Mercaptopurine hydrate 6112-76-1 98%
6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in...
Fludarabine
T1038
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
Vitamin D2
T1086
Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder ...
(S)-crizotinib
T6357
(S)-crizotinib(IC50 of 72 nM), an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
Azelaic acid
T0926
Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular p...
YK-4-279
T2275
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
Capecitabine
T1408
Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively ac...
Enoxacin
T0717L
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
RAD51 Inhibitor B02
T4656
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
dGTP
T40192
dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
RG7800
T12718L
RG7800 has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.
GS-441524
T7222
GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
Resveratrol
T1558
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Fialuridine
T7655
Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and...
β-Boswellic acid
TN1097
Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
Datelliptium chloride hydrochloride
T7747
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
RI-1
T2276
RI-1 is a RAD51 inhibitor (IC50: 5-30 μM).
Pemetrexed disodium
T0189L
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
Hydroxyurea
T0676
Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
2'-Deoxyuridine
T1721
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnos...
6-Mercaptopurine hydrate
T2201
6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in...
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