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DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1508 Decitabine 2353-33-5 99.17%
Decitabine
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic a...
T24871 TFMB-(S)-2-HG 1445703-64-9 98.88%
TFMB-(S)-2-HG
TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl h...
T60322 Procainamide 51-06-9 98.86%
Procainamide
Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide ...
T3089 6-Thioguanine 154-42-7 98.75%
6-Thioguanine
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T7194 CM-272 1846570-31-7 98.21%
CM-272
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T16287 Neurodazine 937807-66-4 98.01%
Neurodazine
Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt...
T8967 SW155246 420092-79-1 97.79%
SW155246
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
T11469 GSK-3484862 2170136-65-7 100%
GSK-3484862
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
T0018 Procainamide hydrochloride 614-39-1 100%
Procainamide hydrochloride
Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog ...
T2169 Zebularine 3690-10-6 100%
Zebularine
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as co...
T5198 Bobcat339 2280037-51-4
Bobcat339
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
T9573 GSK3685032 2170137-61-6 98%
GSK3685032
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
Decitabine
T1508
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic a...
TFMB-(S)-2-HG
T24871
TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl h...
Procainamide
T60322
Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide ...
6-Thioguanine
T3089
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
CM-272
T7194
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Neurodazine
T16287
Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt...
SW155246
T8967
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
GSK-3484862
T11469
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
Procainamide hydrochloride
T0018
Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog ...
Zebularine
T2169
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as co...
Bobcat339
T5198
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
GSK3685032
T9573
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
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