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Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13568L BCX 1470 hydrochloride 98.76%
BCX 1470 hydrochloride
BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor...
T64388 3-Phenoxybenzaldehyde 39515-51-0 98.61%
3-Phenoxybenzaldehyde
3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.
T3638 Leukadherin-1 344897-95-6 98.49%
Leukadherin-1
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
T9915 Eculizumab 219685-50-4 98.20%
Eculizumab
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
T0945 Cyclosporin A 59865-13-3 98%
Cyclosporin A
Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibi...
T38287 C3a Receptor Agonist 944997-60-8 97.5%
C3a Receptor Agonist
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR preve...
TP1304 Compstatin 206645-99-0 100%
Compstatin
Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.
T7497L C3a 70-77 2TFA(63555-63-5(free base)) T7497L 98%
C3a 70-77 2TFA(63555-63-5(free base))
C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a.
TP2180L Compstatin control peptide acetate 301544-78-5 98%
Compstatin control peptide acetate
Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.
T24524 NDT 9513727 439571-48-9 98%
NDT 9513727
NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.
T76702 Sutimlimab 2049079-64-1 98%
Sutimlimab
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemol...
T76831 Tesidolumab 1531594-08-7 98%
Tesidolumab
Tesidolumab (LFG316) is a fully human IgG1/λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cuttin...
T76867 Ravulizumab 1803171-55-2 98%
Ravulizumab
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity...
T38332 Complement factor D-IN-2 1903742-34-6 98%
Complement factor D-IN-2
Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.
T40646 Lipoteichoic acid 56411-57-5 98%
Lipoteichoic acid
Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition v...
T7776 ADH-503 2055362-74-6 98%
ADH-503
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
TP2296L TLQP 21 acetate 98%
TLQP 21 acetate
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human...
T17250 W-54011 405098-33-1 98%
W-54011
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a...
BCX 1470 hydrochloride
T13568L
BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor...
3-Phenoxybenzaldehyde
T64388
3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.
Leukadherin-1
T3638
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
Eculizumab
T9915
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
Cyclosporin A
T0945
Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibi...
C3a Receptor Agonist
T38287
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR preve...
Compstatin
TP1304
Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.
C3a 70-77 2TFA(63555-63-5(free base))
T7497L
C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a.
Compstatin control peptide acetate
TP2180L
Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.
NDT 9513727
T24524
NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.
Sutimlimab
T76702
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemol...
Tesidolumab
T76831
Tesidolumab (LFG316) is a fully human IgG1/λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cuttin...
Ravulizumab
T76867
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity...
Complement factor D-IN-2
T38332
Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.
Lipoteichoic acid
T40646
Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition v...
ADH-503
T7776
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
TLQP 21 acetate
TP2296L
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human...
W-54011
T17250
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a...
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TargetMol