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Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15024 Silmitasertib sodium salt 1309357-15-0 99.49%
Silmitasertib sodium salt
Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
T2259 Silmitasertib 1009820-21-6 99.47%
Silmitasertib
Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
T60295 Casein kinase 1δ-IN-1 851871-94-8 99.46%
Casein kinase 1δ-IN-1
Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ. Casein kinase 1δ-IN-1 can be used in the study of neurodegene...
T2695 TBB 17374-26-4 99.45%
TBB
TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
T60067 WAY-297174 442571-27-9 99.43%
WAY-297174
WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
T3073 PF-670462 950912-80-8 99.42%
PF-670462
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
T64350 Casein kinase 1δ-IN-3 349438-77-3 99.42%
Casein kinase 1δ-IN-3
Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.
T71339 BMS-863233 HCl 1169562-71-3 99.42%
BMS-863233 HCl
BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
T16528 PI-828 942289-87-4 99.39%
PI-828
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differen...
T21915 TBCA 934358-00-6 99.31%
TBCA
TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 ove...
T6208 AS-252424 900515-16-4 99.26%
AS-252424
AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.
T6315 MLN8054 869363-13-3 99.05%
MLN8054
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
T77500 Casein kinase 1δ-IN-6 1579991-01-7 99%
Casein kinase 1δ-IN-6
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-...
T10827 CK2/ERK8-IN-1 1085822-09-8 98.82%
CK2/ERK8-IN-1
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
T10687 Casein Kinase II Inhibitor IV 863598-09-8 98.81%
Casein Kinase II Inhibitor IV
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
T5393 CK1-IN-1 1784751-20-7 98.79%
CK1-IN-1
CK1-IN-1 (PUN51207), compound 1c reported in patent WO2015119579A1, is a casein kinase 1 (CK1) inhibitor. It has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε,...
T60005 CK1-IN-3 349438-74-0 98.70%
CK1-IN-3
CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, infla...
T13004 SSTC3 1242422-09-8 98.65%
SSTC3
SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
T77708 Casein kinase 1δ-IN-7 764694-25-9 98.6%
Casein kinase 1δ-IN-7
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.
T12237 NMS-P715 1202055-32-0 98.41%
NMS-P715
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
Silmitasertib sodium salt
T15024
Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Silmitasertib
T2259
Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
Casein kinase 1δ-IN-1
T60295
Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ. Casein kinase 1δ-IN-1 can be used in the study of neurodegene...
TBB
T2695
TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
WAY-297174
T60067
WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
PF-670462
T3073
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
Casein kinase 1δ-IN-3
T64350
Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.
BMS-863233 HCl
T71339
BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
PI-828
T16528
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differen...
TBCA
T21915
TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 ove...
AS-252424
T6208
AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.
MLN8054
T6315
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
Casein kinase 1δ-IN-6
T77500
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-...
CK2/ERK8-IN-1
T10827
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
Casein Kinase II Inhibitor IV
T10687
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
CK1-IN-1
T5393
CK1-IN-1 (PUN51207), compound 1c reported in patent WO2015119579A1, is a casein kinase 1 (CK1) inhibitor. It has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε,...
CK1-IN-3
T60005
CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, infla...
SSTC3
T13004
SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
Casein kinase 1δ-IN-7
T77708
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.
NMS-P715
T12237
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
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TargetMol