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Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4453 JD-5037 1392116-14-1 98.87%
JD-5037
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
T8975 PSB-SB-487 1399049-81-0 98.78%
PSB-SB-487
PSB-SB-487 is antagonist of GPR55.
T14046 Anandamide 94421-68-8 98.76%
Anandamide
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also ...
T2S0271 Voacamine 3371-85-5 98.73%
Voacamine
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein ...
T6755 AM1241 444912-48-5 98.72%
AM1241
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T19094 2,3-Butanediol 513-85-9 98.64%
2,3-Butanediol
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources which has great potential for diverse industries, including chemical, cosmetic...
T29930 AM-1235 335161-27-8 98.62%
AM-1235
AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.
T7316 LY2828360 1231220-79-3 98.61%
LY2828360
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
T62761 CB1 agonist 1 851212-80-1 98.56%
CB1 agonist 1
CB1 agonist 1 is a potent CB1 agonist with a pIC50 value of 5.7 for CB1 receptors.CB1 agonist 1 can be used to study brain disorders, pain, and inflammation.
T41230 CB 65 913534-05-1 98.39%
CB 65
CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
T28468 PSNCBAM-1 877202-74-9 98.18%
PSNCBAM-1
PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies....
T61562 CB1R Allosteric modulator 3 2633686-36-7 98.18%
CB1R Allosteric modulator 3
CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nic...
T37075 CB2R PAM 2244579-87-9 98.17%
CB2R PAM
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]G...
T22009 CB2 receptor agonist 2 1314230-75-5 98.07%
CB2 receptor agonist 2
CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high a...
T1519L Rimonabant 168273-06-1 98%
Rimonabant
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its m...
T2635 Org 27569 868273-06-7 98%
Org 27569
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
T5996 CB1-IN-1 1429239-98-4 98%
CB1-IN-1
CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T3699 Bay 59-3074 406205-74-1 98%
Bay 59-3074
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
T7375 A-836339 959746-77-1 98%
A-836339
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
T3S0738 Yangonin 500-62-9 98%
yangonin
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
JD-5037
T4453
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
PSB-SB-487
T8975
PSB-SB-487 is antagonist of GPR55.
Anandamide
T14046
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also ...
Voacamine
T2S0271
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein ...
AM1241
T6755
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
2,3-Butanediol
T19094
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources which has great potential for diverse industries, including chemical, cosmetic...
AM-1235
T29930
AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.
LY2828360
T7316
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
CB1 agonist 1
T62761
CB1 agonist 1 is a potent CB1 agonist with a pIC50 value of 5.7 for CB1 receptors.CB1 agonist 1 can be used to study brain disorders, pain, and inflammation.
CB 65
T41230
CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
PSNCBAM-1
T28468
PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies....
CB1R Allosteric modulator 3
T61562
CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nic...
CB2R PAM
T37075
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]G...
CB2 receptor agonist 2
T22009
CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high a...
Rimonabant
T1519L
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its m...
Org 27569
T2635
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
CB1-IN-1
T5996
CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
Bay 59-3074
T3699
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
A-836339
T7375
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
yangonin
T3S0738
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
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TargetMol