T12269 |
NUCC-390
|
1060524-97-1
|
98.18%
|
|
NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compou...
|
T11693L |
IT1t dihydrochloride
|
1092776-63-0
|
98.03%
|
|
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
|
T5193 |
Danirixin
|
954126-98-8
|
98%
|
|
Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
|
T7130 |
Navarixin
|
473727-83-2
|
98%
|
|
Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil traf...
|
T4163 |
Reparixin
|
266359-83-5
|
98%
|
|
Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly...
|
T26035 |
Rac-NBI-74330
|
473722-68-8
|
97.85%
|
|
rac-NBI-74330 is an effective and selective CXCR3 antagonist.
|
T16850 |
SB-265610
|
211096-49-0
|
97.67%
|
|
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calciu...
|
T15805L |
LY2510924 acetate(1088715-84-7 free base)
|
T15805L
|
97.32%
|
|
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
|
T12705 |
Reparixin L-lysine salt
|
266359-93-7
|
97.31%
|
|
Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
|
T6764L |
ATI-2341 acetate(1337878-62-2 free base)
|
T6764L
|
97.14%
|
|
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein (G...
|
T3992 |
MSX-122
|
897657-95-3
|
97.02%
|
|
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
|
T1955 |
SB225002
|
182498-32-4
|
96.86%
|
|
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
|
T11179 |
Elubrixin
|
688763-64-6
|
100.00%
|
|
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory disea...
|
T1776 |
Plerixafor
|
110078-46-1
|
100%
|
|
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
|
T5849 |
JMS-17-2
|
1380392-05-1
|
|
|
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
|
T9721 |
ML339
|
2579689-83-9
|
98%
|
|
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
|
TP2112L |
TC14012 acetate
|
TP2112L
|
98%
|
|
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent C...
|
T14384 |
AZD8797
|
911715-90-7
|
98%
|
|
AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially pr...
|
TQ0174 |
Mavorixafor
|
558447-26-0
|
98%
|
|
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the rep...
|
T76662 |
Ac-Pro-Gly-Pro-OH
|
292171-04-1
|
98%
|
|
Ac-Pro-Gly-Pro-OH is an acetyl-modified tripeptide compound that acts as a CXCR2 agonist.Ac-Pro-Gly-Pro-OH exhibits bactericidal and anti-inflammatory activity, ...
|