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CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3047 SRT3109 1204707-71-0 99.92%
SRT3109
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
T0617 Nicotinamide N-oxide 1986-81-8 99.9%
Nicotinamide N-oxide
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD...
T3327 Artemotil 75887-54-6 99.76%
Artemotil
Artemotil (SM-227) is a new, fast-acting antimalarial drug.
T17208 USL311 1373268-67-7 99.73%
USL311
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation an...
T5207 LIT927 2172879-52-4 99.73%
LIT927
LIT927 (LIT-927) is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).
TP2112L TC14012 acetate TP2112L 99.71%
TC14012 acetate
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent C...
TP1348 FC131 TFA (606968-52-9 free base) 842166-42-1 99.67%
FC131 TFA (606968-52-9 free base)
FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv act...
T4032 MSX-127 6616-56-4 99.61%
MSX-127
MSX-127 elicites positive response in peptide CXCR4.
T7499 TAK-779 229005-80-5 99.58%
TAK-779
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T8497 SX-682 1648843-04-2 99.57%
SX-682
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
T10905 CXCR2-IN-1 1873376-49-8 99.53%
CXCR2-IN-1
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T39078 CXCR7 antagonist-1 1613021-99-0 99.51%
CXCR7 antagonist-1
CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7. CXCR7 antagonist-1 prevents tumor cel...
T13324 VUF11207 fumarate 1785665-61-3 99.5%
VUF11207 fumarate
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
T4033 MSX-130 4051-59-6 99.44%
MSX-130
MSX-130 is CXCR4 Antagonist.
T68052 Delmetacin 16401-80-2 99.42%
Delmetacin
Delmetacin (Demethacin) is a non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity and inhibitory effects on the CXC chemokine r...
T25131 AZD8309 333742-48-6 99.17%
AZD8309
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas a...
T7208 AMD 3465 hexahydrobromide 185991-07-5 99.03%
AMD 3465 hexahydrobromide
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
T7681 AZD-5069 878385-84-3 98.85%
AZD-5069
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
T3396 Baohuoside I 113558-15-9 98.85%
Baohuoside I
Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
T2477 UNBS5162 956590-23-1 98.38%
UNBS5162
UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
SRT3109
T3047
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
Nicotinamide N-oxide
T0617
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD...
Artemotil
T3327
Artemotil (SM-227) is a new, fast-acting antimalarial drug.
USL311
T17208
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation an...
LIT927
T5207
LIT927 (LIT-927) is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).
TC14012 acetate
TP2112L
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent C...
FC131 TFA (606968-52-9 free base)
TP1348
FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv act...
MSX-127
T4032
MSX-127 elicites positive response in peptide CXCR4.
TAK-779
T7499
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
SX-682
T8497
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
CXCR2-IN-1
T10905
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
CXCR7 antagonist-1
T39078
CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7. CXCR7 antagonist-1 prevents tumor cel...
VUF11207 fumarate
T13324
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
MSX-130
T4033
MSX-130 is CXCR4 Antagonist.
Delmetacin
T68052
Delmetacin (Demethacin) is a non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity and inhibitory effects on the CXC chemokine r...
AZD8309
T25131
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas a...
AMD 3465 hexahydrobromide
T7208
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
AZD-5069
T7681
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
Baohuoside I
T3396
Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
UNBS5162
T2477
UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
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TargetMol