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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16169 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 4272-74-6 97.44%
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
TN2440 Sinapyl alcohol 537-33-7 97.28%
Sinapyl alcohol
Technical grade is a natural from Magnolia sieboldii
TN1373 α-Humulene 6753-98-6 97.18%
α-Humulene
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory e...
T1296 4-Aminosalicylic acid 65-49-6 97.07%
4-Aminosalicylic acid
4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T6574 Lumiracoxib 220991-20-8 96.64%
Lumiracoxib
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
T3500 Flurbiprofen Axetil 91503-79-6 96.02%
Flurbiprofen Axetil
Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.
T10152 4-Methylamino antipyrine 519-98-2 95.85%
4-Methylamino antipyrine
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
TN1043 Keracyanin chloride 18719-76-1 95%
Keracyanin chloride
Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin compound, exhibits antioxidant properties. It effectively prevents the formation of malonald...
T10109 3-Carene 13466-78-9 92.18%
3-Carene
3-Carene(Delta-3-Carene) is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infi...
T3S1553 Trans-Cinnamaldehyde 14371-10-9 83%
trans-Cinnamaldehyde
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inh...
T0778 Phenacetin 62-44-2 100%
Phenacetin
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the marke...
T3866 Macelignan 107534-93-0 100%
Macelignan
Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus speci...
T0463L Loxoprofen sodium 80382-23-6 100%
Loxoprofen sodium
Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by re...
T12862 SC58451 168433-84-9 100%
SC58451
SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.
T6S2023 Harpagoside 19210-12-9 100%
Harpagoside
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit li...
T6498 Fenoprofen calcium hydrate 71720-56-4 100%
Fenoprofen calcium hydrate
Fenoprofen calcium hydrate (Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
T0005 Aspirin 50-78-2 100%
Aspirin
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
T0448 (S)-(+)-Ibuprofen 51146-56-6 100%
(S)-(+)-Ibuprofen
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T15687 Thioflosulide 158205-05-1 100%
Thioflosulide
Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.
T68126 Pemedolac 114716-16-4 100%
Pemedolac
Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
T16169
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
Sinapyl alcohol
TN2440
Technical grade is a natural from Magnolia sieboldii
α-Humulene
TN1373
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory e...
4-Aminosalicylic acid
T1296
4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
Lumiracoxib
T6574
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
Flurbiprofen Axetil
T3500
Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.
4-Methylamino antipyrine
T10152
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
Keracyanin chloride
TN1043
Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin compound, exhibits antioxidant properties. It effectively prevents the formation of malonald...
3-Carene
T10109
3-Carene(Delta-3-Carene) is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infi...
trans-Cinnamaldehyde
T3S1553
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inh...
Phenacetin
T0778
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the marke...
Macelignan
T3866
Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus speci...
Loxoprofen sodium
T0463L
Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by re...
SC58451
T12862
SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.
Harpagoside
T6S2023
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit li...
Fenoprofen calcium hydrate
T6498
Fenoprofen calcium hydrate (Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
Aspirin
T0005
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
(S)-(+)-Ibuprofen
T0448
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Thioflosulide
T15687
Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.
Pemedolac
T68126
Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.
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TargetMol