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CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7698 BS194 1092443-55-4 99.64%
BS194
BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.
T12642 (R)-Simurosertib 1330782-69-8 99.64%
(R)-Simurosertib
(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.
T22106 MLS-573151 10179-57-4 99.64%
MLS-573151
MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 ...
T8430 Senexin B 1449228-40-3 99.63%
Senexin B
Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).
T8930 CID44216842 1222513-26-9 99.63%
CID44216842
CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM...
T61439 DSS30 883027-32-5 99.61%
DSS30
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of...
T3166 VX-11e 896720-20-0 99.6%
VX-11e
VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
T21720 GP-82996 359886-84-3 99.57%
GP-82996
GP-82996 (CINK4) (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC 50 s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, re...
T15732 Ribociclib succinate 1374639-75-4 99.57%
Ribociclib succinate
Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent again...
T6139L A-674563 2HCl(552325-73-2(fb-2hcl)) T6139L 99.57%
A-674563 2HCl(552325-73-2(fb-2hcl))
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T23589 9-Isopropylolomoucine 158982-15-1 99.56%
9-Isopropylolomoucine
9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.
T15454 GW843682X 660868-91-7 99.56%
GW843682X
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
T39752 CDK12-IN-2 2244987-03-7 99.54%
CDK12-IN-2
CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9....
T2029 Bohemine 189232-42-6 99.53%
Bohemine
Bohemine is a cyclin-dependent kinase inhibitor.
TQ0078 CDK-IN-2 1269815-17-9 99.52%
CDK-IN-2
CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).
T22461 YKL-5-124 1957203-01-8 99.5%
YKL-5-124
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays ...
T6177 PF-562271 besylate 939791-38-5 99.5%
PF-562271 besylate
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK a...
T8801 SRI-29329 2086809-58-5 99.49%
SRI-29329
SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).
T7444 6-(Dimethylamino)purine 938-55-6 99.49%
6-(Dimethylamino)purine
6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor
T77619 WAY-322243 332939-32-9 99.47%
WAY-322243
WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.
BS194
T7698
BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.
(R)-Simurosertib
T12642
(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.
MLS-573151
T22106
MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 ...
Senexin B
T8430
Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).
CID44216842
T8930
CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM...
DSS30
T61439
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of...
VX-11e
T3166
VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
GP-82996
T21720
GP-82996 (CINK4) (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC 50 s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, re...
Ribociclib succinate
T15732
Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent again...
A-674563 2HCl(552325-73-2(fb-2hcl))
T6139L
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
9-Isopropylolomoucine
T23589
9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.
GW843682X
T15454
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
CDK12-IN-2
T39752
CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9....
Bohemine
T2029
Bohemine is a cyclin-dependent kinase inhibitor.
CDK-IN-2
TQ0078
CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).
YKL-5-124
T22461
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays ...
PF-562271 besylate
T6177
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK a...
SRI-29329
T8801
SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).
6-(Dimethylamino)purine
T7444
6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor
WAY-322243
T77619
WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.
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TargetMol