CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T2247	KenPaullone	142273-20-9	98%
T2247	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differenti...
T7296	THZ2	1604810-84-5	98%
T7296	THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).
T7167	Purvalanol B	212844-54-7	98%
T7167	Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)
T5673	Senexin A	1366002-50-7	98%
T5673	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.
T5533	MC180295	2237942-08-2	98%
T5533	MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.
T3111	Abemaciclib methanesulfonate	1231930-82-7	98%
T3111	Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
T39403	Avotaciclib	1983983-41-0	97.98%
T39403	Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastatic pa...
T118066	CDK9 inhibitor HH1	204188-41-0	97.97%
T118066	CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.
T62702	Senexin C	2375554-02-0	97.91%
T62702	Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senex...
T6169	Indirubin	479-41-4	97.86%
T6169	Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
T3195	CVT-313	199986-75-9	97.82%
T3195	CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.
T5395	BSJ-03-123	2361493-16-3	97.78%
T5395	BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
T2032	WHI-P180	211555-08-7	97.74%
T2032	WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
T14901	CCT-251921	1607837-31-9	97.74%
T14901	CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).
T2465	PF-562271	717907-75-0	97.65%
T2465	PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T60025	Eciruciclib	1868086-40-1	97.51%
T60025	Eciruciclib is an inhibitor of CDK with antitumor properties.
T60012	HS-243	848249-10-5	97.34%
T60012	HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
T16750	Rigosertib	592542-59-1	97.33%
T16750	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer a...
T2378	RGB-286638 free base	784210-88-4	97.29%
T2378	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
T14916	CDK2-IN-4	2079895-42-2	97.24%
T14916	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86...