CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T16391	ON-013100	865783-95-5	98.27%
T16391	ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.
T15204	EHT 1610	1425945-60-3	98.27%
T15204	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on ...
T9138	Indirubin-3′-oxime	667463-82-3	98.26%
T9138	Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
T4051	LDC4297	1453834-21-3	98.25%
T4051	LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.
T10659	Ca2+ channel agonist 1	1402821-24-2	98.21%
T10659	Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor...
T34888	TL12-186	2250025-88-6	98.2%
T34888	TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with I...
T10745	CDK9-IN-7	2369981-71-3	98.19%
T10745	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/c...
T10744L	SEL120-34A HCl	1609452-30-3	98.13%
T10744L	SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), ...
T14919	CDKI-73	1421693-22-2	98.11%
T14919	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The in...
T9083	TC11	100823-03-8	98.1%
T9083	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis vi...
T74710	YX-2-107	2417408-46-7	98.09%
T74710	YX-2-107 is a selective and potent CDK6-degrading PROTAC with an IC50 value of 4.4 nM.YX-2-107 inhibits RB phosphorylation and FOXM1 expression in vitro, and inh...
T77810	XPW1	2700286-66-2	98.08%
T77810	XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used...
T13058	T025	2407433-00-3	98.08%
T13058	T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 3...
T16021	MBQ-167	2097938-73-1	98.07%
T16021	MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).
TN1222	26-Deoxyactein	264624-38-6	98.06%
TN1222	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity...
T70388	(S)-Enitociclib	1610408-97-3	98.04%
T70388	(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription ...
T16359	NU6140	444723-13-1	98.04%
T16359	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A ...
T74643	RSS0680	2769753-48-0	98.02%
T74643	RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.
T4135	OTS964 hydrochloride	1338545-07-5	98.02%
T4135	OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.
T9078	LY3405105	2326428-25-3	98.01%
T9078	LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrr...