CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T12809	(S)-PF-06873600	2185859-59-8	98.55%
T12809	(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.
T23601	ABC1183	1042735-18-1	98.53%
T23601	ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival b...
T21768	PF-562271 hydrochloride	939791-41-0	98.52%
T21768	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
T10550	Bisindolylmaleimide X hydrochloride	145317-11-9	98.5%
T10550	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T2246	LRRK2-IN-1	1234480-84-2	98.44%
T2246	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T9064	LY3143921 hydrate	1627696-53-0	98.43%
T9064	LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].
T64373	CDK1-IN-2	220749-41-7	98.41%
T64373	CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several ...
T24152	HTH-01-091	2000209-42-5	98.40%
T24152	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T4227	SB1317 hydrochloride (1204918-72-8(free base))	T4227	98.39%
T4227	SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).
T11961	MBM-55S	2083624-07-9	98.38%
T11961	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
T72057	H1k		98.38%
T72057	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulat...
T14367	AZ1495	2196204-23-4	98.36%
T14367	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. W...
T2517	SCH900776	891494-63-6	98.35%
T2517	SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
T6028	PF 477736	952021-60-2	98.34%
T6028	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
T35332	THZ1 2HCl	2095433-94-4	98.33%
T35332	THZ1 2HCl (THZ1 Dihydrochloride) is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a ...
T2679	BMS-265246	582315-72-8	98.33%
T2679	BMS-265246 is a potent and selective CDK1/2 inhibitor.
T9636	Dalpiciclib	1637781-04-4	98.32%
T9636	Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respective...
T1830	BX795	702675-74-9	98.32%
T1830	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T16391	ON-013100	865783-95-5	98.27%
T16391	ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.
T15204	EHT 1610	1425945-60-3	98.27%
T15204	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on ...