T9117 |
BSJ-4-116
|
2519823-34-6
|
99.09%
|
|
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcript...
|
T4321 |
Indisulam
|
165668-41-7
|
99.07%
|
|
Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing...
|
T6563 |
LDC000067
|
1073485-20-7
|
99.07%
|
|
LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
|
T77613 |
SNX7
|
685097-43-2
|
99.05%
|
|
SNX7 (WAY-323879) is an inhibitor of the cell cycle protein-dependent kinase inhibitor (CDKI) pathway. SNX7 can be utilized as a tool for investigating the aging...
|
T14918 |
CDK9-IN-2
|
1263369-28-3
|
99%
|
|
CDK9-IN-2 is a special CDK9 inhibitor extracted from patent WO/2012131594A1 (compound CDKI(8)) and has an IC50 of 5 nM and 7 nM in A2058 skin cell line (72 hours...
|
T72048 |
CDK8-IN-12
|
2613307-67-6
|
98.97%
|
|
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with ...
|
T8576 |
P18IN011
|
77408-67-4
|
98.94%
|
|
P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).
|
TN1299 |
Desmethylglycitein
|
17817-31-1
|
98.93%
|
|
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant...
|
T4205 |
AG-494
|
133550-35-3
|
98.9%
|
|
AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
|
T2670 |
ML167
|
1285702-20-6
|
98.85%
|
|
ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
|
T21966 |
MeBIO
|
667463-95-8
|
98.84%
|
|
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
|
T36933 |
Cdk2 Inhibitor II
|
222035-13-4
|
98.84%
|
|
Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.
|
T70388L |
(R)-Enitociclib
|
1610408-96-2
|
98.82%
|
|
(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.
|
T14778 |
BRD6989
|
642008-81-9
|
98.82%
|
|
BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant C...
|
T10746 |
CDK9-IN-8
|
2105956-51-0
|
98.77%
|
|
CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).
|
T77341 |
GSK-3 inhibitor 4
|
2227279-83-4
|
98.77%
|
|
GSK-3 inhibitor 4 is an orally active and brain-permeable triple inhibitor of GSK-3, CDK2 and CDK5 with inhibitory effects on GSK-3β, GSK-3α, CDK2 and CDK5, with...
|
T1901 |
(E/Z)-TG003
|
300801-52-9
|
98.73%
|
|
(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.
|
T23897 |
CLK1/2-IN-3
|
1005784-60-0
|
98.71%
|
|
CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, an...
|
TQ0053 |
Fadraciclib
|
1070790-89-4
|
98.71%
|
|
Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).
|
T6940 |
PHA-767491 hydrochloride
|
942425-68-5
|
98.69%
|
|
PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against...
|