T6708 |
Tolcapone
|
134308-13-7
|
99.49%
|
|
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa an...
|
T67751 |
1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
|
539807-13-1
|
99.44%
|
|
Compound 5936-0108 may has modulationg effect on β-Amyloid (patent WO 2007/134449).
|
T9713 |
δ-secretase inhibitor 11
|
842964-18-5
|
99.4%
|
|
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
|
TN2082 |
Pinostrobin
|
480-37-5
|
99.35%
|
|
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
|
T12532 |
PQM130
|
2089415-51-8
|
99.31%
|
|
PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.
|
T3259 |
FPS-ZM1
|
945714-67-0
|
99.3%
|
|
FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
|
T14690 |
BMS 433796
|
935525-13-6
|
99.17%
|
|
BMS 433796 is a γ-secretase inhibitor with Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease.
|
T6125 |
Semagacestat
|
425386-60-3
|
99.11%
|
|
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
|
T6S1918 |
Schisantherin B
|
58546-55-7
|
99.06%
|
|
1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hep...
|
T4364 |
Aftin-4
|
866893-90-5
|
99.03%
|
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin...
|
T2639 |
LY2811376
|
1194044-20-6
|
99.01%
|
|
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
|
T2777 |
Ginsenoside Rg1
|
22427-39-0
|
99%
|
|
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spat...
|
T0883 |
Tramiprosate
|
3687-18-1
|
99%
|
|
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble A...
|
T2625 |
MK-0752
|
471905-41-6
|
98.99%
|
|
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
|
T19011L |
Hoechst 34580 xHCl(23555-00-2(free base)
|
T19011L
|
98.89%
|
|
Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
|
T2212 |
Geniposide
|
24512-63-8
|
98.78%
|
|
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activit...
|
T5447 |
Anle138b
|
882697-00-9
|
98.76%
|
|
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
|
TP2419 |
V-9-M Cholecystokinin nonapeptide
|
99291-20-0
|
98.75%
|
|
V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) is a precursor compound of cholecystokinin (CCK). Cholecystokinin (CCK) is a brain-intestinal pepti...
|
TMS1461 |
Qingyangshengenin B
|
106758-54-7
|
98.56%
|
|
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases...
|
T14283 |
Amyloid P-IN-1
|
1819986-22-5
|
98.03%
|
|
amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and t...
|