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Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6708 Tolcapone 134308-13-7 99.49%
Tolcapone
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa an...
T67751 1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester 539807-13-1 99.44%
1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
Compound 5936-0108 may has modulationg effect on β-Amyloid (patent WO 2007/134449).
T9713 δ-secretase inhibitor 11 842964-18-5 99.4%
δ-secretase inhibitor 11
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
TN2082 Pinostrobin 480-37-5 99.35%
Pinostrobin
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
T12532 PQM130 2089415-51-8 99.31%
PQM130
PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.
T3259 FPS-ZM1 945714-67-0 99.3%
FPS-ZM1
FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
T14690 BMS 433796 935525-13-6 99.17%
BMS 433796
BMS 433796 is a γ-secretase inhibitor with Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease.
T6125 Semagacestat 425386-60-3 99.11%
Semagacestat
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T6S1918 Schisantherin B 58546-55-7 99.06%
Schisantherin B
1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hep...
T4364 Aftin-4 866893-90-5 99.03%
Aftin-4
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin...
T2639 LY2811376 1194044-20-6 99.01%
LY2811376
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
T2777 Ginsenoside Rg1 22427-39-0 99%
Ginsenoside Rg1
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spat...
T0883 Tramiprosate 3687-18-1 99%
Tramiprosate
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble A...
T2625 MK-0752 471905-41-6 98.99%
MK-0752
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T19011L Hoechst 34580 xHCl(23555-00-2(free base) T19011L 98.89%
Hoechst 34580 xHCl(23555-00-2(free base)
Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T2212 Geniposide 24512-63-8 98.78%
Geniposide
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activit...
T5447 Anle138b 882697-00-9 98.76%
Anle138b
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
TP2419 V-9-M Cholecystokinin nonapeptide 99291-20-0 98.75%
V-9-M Cholecystokinin nonapeptide
V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) is a precursor compound of cholecystokinin (CCK). Cholecystokinin (CCK) is a brain-intestinal pepti...
TMS1461 Qingyangshengenin B 106758-54-7 98.56%
Qingyangshengenin B
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases...
T14283 Amyloid P-IN-1 1819986-22-5 98.03%
amyloid P-IN-1
amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and t...
Tolcapone
T6708
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa an...
1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
T67751
Compound 5936-0108 may has modulationg effect on β-Amyloid (patent WO 2007/134449).
δ-secretase inhibitor 11
T9713
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
Pinostrobin
TN2082
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
PQM130
T12532
PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.
FPS-ZM1
T3259
FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
BMS 433796
T14690
BMS 433796 is a γ-secretase inhibitor with Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease.
Semagacestat
T6125
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
Schisantherin B
T6S1918
1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hep...
Aftin-4
T4364
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin...
LY2811376
T2639
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
Ginsenoside Rg1
T2777
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spat...
Tramiprosate
T0883
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble A...
MK-0752
T2625
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
Hoechst 34580 xHCl(23555-00-2(free base)
T19011L
Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Geniposide
T2212
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activit...
Anle138b
T5447
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
V-9-M Cholecystokinin nonapeptide
TP2419
V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) is a precursor compound of cholecystokinin (CCK). Cholecystokinin (CCK) is a brain-intestinal pepti...
Qingyangshengenin B
TMS1461
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases...
amyloid P-IN-1
T14283
amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and t...
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TargetMol