T8866 |
GW779439X
|
551919-98-3
|
99.23%
|
|
GW779439X is an inhibitor of CDK.
|
T6039 |
TAK-285
|
871026-44-7
|
99.17%
|
|
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Auro...
|
T9040 |
Aurora kinase inhibitor-2
|
331770-21-9
|
99.15%
|
|
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
|
T6077 |
ZM-447439
|
331771-20-1
|
99.11%
|
|
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective f...
|
T6315 |
MLN8054
|
869363-13-3
|
99.05%
|
|
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
|
T6338 |
PHA-680632
|
398493-79-3
|
99.03%
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
|
T17267 |
XL228
|
898280-07-4
|
98.92%
|
|
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
|
T1886 |
TAK-632
|
1228591-30-7
|
98.92%
|
|
TAK-632 is a potent pan-Raf inhibitor.
|
T6068 |
MK-5108
|
1010085-13-8
|
98.76%
|
|
MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.
|
T14927 |
Centrinone
|
1798871-30-3
|
98.76%
|
|
Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
|
T34787 |
TAS-119
|
1453099-83-6
|
98.69%
|
|
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM...
|
T6129 |
GSK-1070916
|
942918-07-2
|
98.51%
|
|
GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the ...
|
T2602 |
Barasertib-HQPA
|
722544-51-6
|
98.46%
|
|
Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.
|
T2094 |
Danusertib
|
827318-97-8
|
98.44%
|
|
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinase...
|
T11961 |
MBM-55S
|
2083624-07-9
|
98.38%
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
|
T12010 |
Aurora B inhibitor 1
|
937276-52-3
|
98.37%
|
|
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.
|
T6028 |
PF 477736
|
952021-60-2
|
98.34%
|
|
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
|
T2620 |
G-749
|
1457983-28-6
|
98.32%
|
|
G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
|
T21981 |
Phthalazinone pyrazole
|
880487-62-7
|
98.22%
|
|
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and disp...
|
T6532 |
Hesperadin
|
422513-13-1
|
98.04%
|
|
Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK...
|