Aurora Kinase

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis.

Cat. No.	Product name	CAS No.	Purity
T64338	AKI603	1432515-73-5	99.81%
T64338	AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutati...
T29170	XU1	53439-81-9	99.79%
T29170	XU1（Benzo[c][1,8]naphthyridin-6(5h)-One） is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation or modulati...
T22012	7BIO	916440-85-2	99.77%
T22012	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
T1825	Reversine	656820-32-5	99.75%
T1825	Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).
T6767	TCS7010	1158838-45-9	99.69%
T6767	TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective f...
T3166	VX-11e	896720-20-0	99.67%
T3166	VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
T6126	JNJ-7706621	443797-96-4	99.66%
T6126	JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.
T2718	Palmatine chloride	10605-02-4	99.64%
T2718	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T14371	Barasertib	722543-31-9	99.63%
T14371	AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
T3109	SP600125	129-56-6	99.58%
T3109	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive proper...
T15454	GW843682X	660868-91-7	99.56%
T15454	GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
T41256	SP-96	2682114-54-9	99.52%
T41256	SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including M...
T50110	CD532	1639009-81-6	99.49%
T50110	CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directl...
T5S0802	Palmatine	3486-67-7	99.49%
T5S0802	1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palma...
T15815	LY3295668	1919888-06-4	99.44%
T15815	LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.
T2471	MK-8745	885325-71-3	99.31%
T2471	MK-8745 is a potent and selective Aurora A inhibitor.
T8866	GW779439X	551919-98-3	99.23%
T8866	GW779439X is an inhibitor of CDK.
T6039	TAK-285	871026-44-7	99.17%
T6039	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Auro...
T9040	Aurora kinase inhibitor-2	331770-21-9	99.15%
T9040	Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
T6077	ZM-447439	331771-20-1	99.11%
T6077	ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective f...