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Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6817 Deguelin 522-17-8 96.39%
Deguelin
Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
T9393 (E)-Akt inhibitor-IV 959841-49-7 100.00%
(E)-Akt inhibitor-IV
(E)-Akt inhibitor-IV ((E)-AKTIV)  ((E)-AKTIV) is an inhibitor of PI3K-Akt.
T7885 Afuresertib hydrochloride 1047645-82-8 100%
Afuresertib hydrochloride
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T7879 TASP0415914 1292300-75-4 100%
TASP0415914
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
T6065 Triciribine 35943-35-2 100%
Triciribine
Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
T3S0209 Vincristine 57-22-7 100%
Vincristine
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
T7190 Actein 18642-44-9
Actein
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
T7315 BAY1125976 1402608-02-9
BAY1125976
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
T13862 Recilisib 334969-03-8
Recilisib
Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.
T6S0525 Farrerol 24211-30-1 98%
Farrerol
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
T25017 AKT-I-1 473382-39-7 98%
AKT-I-1
AKT-I-1 is a selective and reversible inhibitor of Akt1.
T6849 Uprosertib 1047634-65-0 98%
Uprosertib
Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 a...
T23695 Akt-I-1,2 473382-50-2 98%
Akt-I-1,2
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
T76795 Xentuzumab 1417158-65-6 98%
Xentuzumab
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activ...
T76796 Patritumab 1262787-83-6 98%
Patritumab
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
T4444 A-674563 HCl (552325-73-2(free base)) 2070009-66-2 98%
A-674563 HCl (552325-73-2(free base))
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T15374 Ipatasertib dihydrochloride 1396257-94-5 98%
Ipatasertib dihydrochloride
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and A...
T3399 Psoralidin 18642-23-4 98%
Psoralidin
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T5S0168 Atractylenolide II 73069-14-4 98%
Atractylenolide II
1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p...
T15469 Hematein 475-25-2 98%
Hematein
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
Deguelin
T6817
Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
(E)-Akt inhibitor-IV
T9393
(E)-Akt inhibitor-IV ((E)-AKTIV)  ((E)-AKTIV) is an inhibitor of PI3K-Akt.
Afuresertib hydrochloride
T7885
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
TASP0415914
T7879
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
Triciribine
T6065
Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
Vincristine
T3S0209
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
Actein
T7190
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
BAY1125976
T7315
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
Recilisib
T13862
Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.
Farrerol
T6S0525
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
AKT-I-1
T25017
AKT-I-1 is a selective and reversible inhibitor of Akt1.
Uprosertib
T6849
Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 a...
Akt-I-1,2
T23695
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
Xentuzumab
T76795
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activ...
Patritumab
T76796
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
A-674563 HCl (552325-73-2(free base))
T4444
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
Ipatasertib dihydrochloride
T15374
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and A...
Psoralidin
T3399
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
Atractylenolide II
T5S0168
1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p...
Hematein
T15469
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
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TargetMol