T6817 |
Deguelin
|
522-17-8
|
96.39%
|
|
Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
|
T9393 |
(E)-Akt inhibitor-IV
|
959841-49-7
|
100.00%
|
|
(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.
|
T7885 |
Afuresertib hydrochloride
|
1047645-82-8
|
100%
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
|
T7879 |
TASP0415914
|
1292300-75-4
|
100%
|
|
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
|
T6065 |
Triciribine
|
35943-35-2
|
100%
|
|
Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
|
T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
T7190 |
Actein
|
18642-44-9
|
|
|
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
|
T7315 |
BAY1125976
|
1402608-02-9
|
|
|
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
|
T13862 |
Recilisib
|
334969-03-8
|
|
|
Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.
|
T6S0525 |
Farrerol
|
24211-30-1
|
98%
|
|
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
|
T25017 |
AKT-I-1
|
473382-39-7
|
98%
|
|
AKT-I-1 is a selective and reversible inhibitor of Akt1.
|
T6849 |
Uprosertib
|
1047634-65-0
|
98%
|
|
Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 a...
|
T23695 |
Akt-I-1,2
|
473382-50-2
|
98%
|
|
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
|
T76795 |
Xentuzumab
|
1417158-65-6
|
98%
|
|
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activ...
|
T76796 |
Patritumab
|
1262787-83-6
|
98%
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
|
T4444 |
A-674563 HCl (552325-73-2(free base))
|
2070009-66-2
|
98%
|
|
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
|
T15374 |
Ipatasertib dihydrochloride
|
1396257-94-5
|
98%
|
|
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and A...
|
T3399 |
Psoralidin
|
18642-23-4
|
98%
|
|
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
|
T5S0168 |
Atractylenolide II
|
73069-14-4
|
98%
|
|
1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p...
|
T15469 |
Hematein
|
475-25-2
|
98%
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|