Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.

Cat. No.	Product name	CAS No.	Purity
T5S0896	Loureirin A	119425-89-7	99.84%
T5S0896	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced p...
T2176	2,3-Butanedione 2-Monoxime	57-71-6	99.83%
T2176	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.
T5508	PF-AKT400	1004990-28-6	99.82%
T5508	PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.
T3844	Deltonin	55659-75-1	99.79%
T3844	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), ...
T1911	Afuresertib	1047644-62-1	99.77%
T1911	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity...
T11734	K-80003	1292821-90-9	99.76%
T11734	K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
T3861	Isobavachalcone	20784-50-3	99.76%
T3861	Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in ...
T4S1419	(±)-Praeruptorin A	73069-25-7	99.73%
T4S1419	1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Pr...
T60055	Chromeceptin	331859-86-0	99.72%
T60055	Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.
T1952	MK-2206 dihydrochloride	1032350-13-2	99.69%
T1952	MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and sele...
TN1968	N-Feruloyloctopamine	66648-44-0	99.67%
TN1968	N-Feruloyloctopamine is a natural product.
T6304	AT7867	857531-00-1	99.65%
T6304	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
T13265	Urolithin B	1139-83-9	99.64%
T13265	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical frui...
T4085	Paris saponin VII	68124-04-9	99.63%
T4085	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T60564	PI3K/Akt/mTOR-IN-2	2757804-89-8	99.61%
T60564	PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI...
T3132	SC66	871361-88-5	99.6%
T3132	SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).
T16104	ML-9	105637-50-1	99.6%
T16104	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits...
T3729	Ethyl gallate	831-61-8	99.58%
T3729	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytot...
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	T6139L	99.57%
T6139L	A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T4S0498	Glaucocalyxin A	79498-31-0	99.56%
T4S0498	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase...