AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat. No.	Product name	CAS No.	Purity
T1453	Phenformin hydrochloride	834-28-6	99.15%
T1453	Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T1020	Doxorubicin hydrochloride	25316-40-9	99.13%
T1020	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
T62745	AMPK-IN-3	2417674-27-0	99.13%
T62745	AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, res...
TN1100	Nepodin	3785-24-8	99.12%
TN1100	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T8929	BC1618	2222094-18-8	99.09%
T8929	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It...
T2374	HTH-01-015	1613724-42-7	99.08%
T2374	HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T3S0195	Nootkatone	4674-50-4	99.04%
T3S0195	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
T0800	Danthron	117-10-2	99.03%
T0800	Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T6854	GSK621	1346607-05-3	99.01%
T6854	GSK621 is a specific and potent AMPK activator.
T3546	STO-609	52029-86-4	98.95%
T3546	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL)....
T5S2361	Epiberberine	6873-09-2	98.95%
T5S2361	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
TN1990	Norathyriol	3542-72-1	98.93%
TN1990	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T6146	Dorsomorphin dihydrochloride	1219168-18-9	98.89%
T6146	Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on s...
TN2179	Saponarin	20310-89-8	98.84%
TN2179	Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T6285	GSK-690693	937174-76-0	98.78%
T6285	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T2854	Phillyrin	487-41-2	98.76%
T2854	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking...
T5497	AMAROGENTIN	21018-84-8	98.75%
T5497	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell ...
T19661	8-Chloroadenosine	34408-14-5	98.75%
T19661	8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine acti...
T7955	EB-3D	1839150-63-8	98.75%
T7955	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
T2468	A-769662	844499-71-4	98.72%
T2468	A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).