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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T19659 Annaosanchun 4725-51-3 99.58%
Annaosanchun
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).
T5993 ARN-3236 1613710-01-2 99.57%
ARN-3236
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
TN1731 Hernandezine 6681-13-6 99.53%
Hernandezine
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
T1977 Dorsomorphin 866405-64-3 99.48%
Dorsomorphin
Dorsomorphin (Compound C) is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T3220 Euphorbiasteroid 28649-59-4 99.46%
Euphorbiasteroid
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
T3889 Platycodin D 58479-68-8 99.43%
Platycodin D
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
T19500 Palmitelaidic Acid 10030-73-6 99.36%
Palmitelaidic Acid
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
TN1911 Marein 535-96-6 99.34%
Marein
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
T2746 Sophocarpine monohydrate 145572-44-7 99.33%
Sophocarpine monohydrate
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T78791 AMPK activator 12 431920-24-0 99.27%
AMPK activator 12
AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer r...
T8432 ASP4132 1640294-30-9 99.26%
ASP4132
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
T3405 [6]-Gingerol 23513-14-6 99.25%
[6]-Gingerol
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovarie...
T2S0820 Karanjin 521-88-0 99.24%
Karanjin
Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Ka...
T9191 XMD-17-51 Trifluoroacetate 2436579-93-8 99.22%
XMD-17-51 Trifluoroacetate
XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.
T6920 ON123300 1357470-29-1 99.22%
ON123300
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
TQ0028 EX229 1219739-36-2 99.22%
EX229
EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
T1020 Doxorubicin hydrochloride 25316-40-9 99.13%
Doxorubicin hydrochloride
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
T62745 AMPK-IN-3 2417674-27-0 99.13%
AMPK-IN-3
AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, res...
TN1100 Nepodin 3785-24-8 99.12%
Nepodin
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T8929 BC1618 2222094-18-8 99.09%
BC1618
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signali...
Annaosanchun
T19659
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).
ARN-3236
T5993
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
Hernandezine
TN1731
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
Dorsomorphin
T1977
Dorsomorphin (Compound C) is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
Euphorbiasteroid
T3220
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
Platycodin D
T3889
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
Palmitelaidic Acid
T19500
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
Marein
TN1911
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
Sophocarpine monohydrate
T2746
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
AMPK activator 12
T78791
AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer r...
ASP4132
T8432
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
[6]-Gingerol
T3405
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovarie...
Karanjin
T2S0820
Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Ka...
XMD-17-51 Trifluoroacetate
T9191
XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.
ON123300
T6920
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
EX229
TQ0028
EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
Doxorubicin hydrochloride
T1020
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
AMPK-IN-3
T62745
AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, res...
Nepodin
TN1100
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
BC1618
T8929
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signali...
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TargetMol