T19659 |
Annaosanchun
|
4725-51-3
|
99.58%
|
|
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).
|
T5993 |
ARN-3236
|
1613710-01-2
|
99.57%
|
|
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
|
TN1731 |
Hernandezine
|
6681-13-6
|
99.53%
|
|
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
|
T1977 |
Dorsomorphin
|
866405-64-3
|
99.48%
|
|
Dorsomorphin (Compound C) is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
|
T3220 |
Euphorbiasteroid
|
28649-59-4
|
99.46%
|
|
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
|
T3889 |
Platycodin D
|
58479-68-8
|
99.43%
|
|
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
|
T19500 |
Palmitelaidic Acid
|
10030-73-6
|
99.36%
|
|
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
|
TN1911 |
Marein
|
535-96-6
|
99.34%
|
|
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
|
T2746 |
Sophocarpine monohydrate
|
145572-44-7
|
99.33%
|
|
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
T78791 |
AMPK activator 12
|
431920-24-0
|
99.27%
|
|
AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer r...
|
T8432 |
ASP4132
|
1640294-30-9
|
99.26%
|
|
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
|
T3405 |
[6]-Gingerol
|
23513-14-6
|
99.25%
|
|
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovarie...
|
T2S0820 |
Karanjin
|
521-88-0
|
99.24%
|
|
Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Ka...
|
T9191 |
XMD-17-51 Trifluoroacetate
|
2436579-93-8
|
99.22%
|
|
XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.
|
T6920 |
ON123300
|
1357470-29-1
|
99.22%
|
|
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
|
TQ0028 |
EX229
|
1219739-36-2
|
99.22%
|
|
EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
|
T1020 |
Doxorubicin hydrochloride
|
25316-40-9
|
99.13%
|
|
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
|
T62745 |
AMPK-IN-3
|
2417674-27-0
|
99.13%
|
|
AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, res...
|
TN1100 |
Nepodin
|
3785-24-8
|
99.12%
|
|
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
|
T8929 |
BC1618
|
2222094-18-8
|
99.09%
|
|
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signali...
|