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(1)
By Target- Apoptosis
- Autophagy(1)
- Retinoid Receptor(1)
- Others(2)
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- Cell Cycle/Checkpoint
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Results for "
macroautophagy
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Compound Libraries1
- Recombinant Protein3
Cited
NEO214
T869921361198-80-2
NEO214, an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and blood-brain barrier (BBB) permeability. It prevents autophagy-lysosome fusion, blocking autophagic flux and triggering glioma cell death via mTOR activation and TFEB (Transcription Factor EB) aggregation. NEO214 inhibition of Macroautophagy autophagy in glioblastoma cells may overcome chemotherapy resistance in glioblastoma [1].
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