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(2)
By Target- Apoptosis
- TOPK(2)
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Biochemicals
- Autophagy
- Cell Cycle/Checkpoint
- Cytoskeletal Signaling
- Chromatin/Epigenetic
- Endocrinology/Hormones
- Hedgehog/Smoothened
- Angiogenesis
- DNA Damage/DNA Repair
- Apoptosis
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- NOD
- NOD-like Receptor (NLR)
- NOS
- Nrf2
- PD-1/PD-L1
- PGE Synthase
- Prostaglandin Receptor
- Pyroptosis
- Reactive Oxygen Species
- ROS
- STING
- Thrombopoietin Receptor
- TLR
- EGFR
- HER
- JAK
- Pim
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- Casein Kinase
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- Decarboxylase
- Dehydrogenase
- DHFR
- Drug Metabolite
- Endogenous Metabolite
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- FAAH
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- Fatty Acid Synthase
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- Glucosidase
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- HIF/HIF Prolyl-Hydroxylase
- HMG-CoA Reductase
- HSP
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- Hydroxylase
- IDO
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Results for "
OTS-514
" in TargetMol Product Catalog- Inhibitors & Agonists2
OTS514
T4134L1338540-63-8
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
- $89
Size
QTY
OTS514 hydrochloride
T41342319647-76-0
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
- $56
Size
QTY
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