iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

Cat. No.	Product name	CAS No.	Purity
T62839	Dalzanemdor	1629853-48-0	98.20%
T62839	Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dys...
T12733	Rislenemdaz	808732-98-1	98.18%
T12733	Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
T15623	JNJ-61432059	2035814-50-5	98.13%
T15623	JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1...
T7579	1-BCP	34023-62-6	98%
T7579	1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.
T5522	NMDAR antagonist 1	2220162-06-9	98%
T5522	NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.
T6618	Orphenadrine Citrate	4682-36-4	98%
T6618	Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T7178	CNQX	115066-14-3	98%
T7178	CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T7580	CX546	215923-54-9	98%
T7580	CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.
T1909	L-701324	142326-59-8	98%
T1909	L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T0675	Topiramate	97240-79-4	98%
T0675	Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associate...
T7591	Coluracetam	135463-81-9	98%
T7591	Coluracetam (MKC-231)(MKC-231) is a Choline Uptake Enhancer.
T7108	Omberacetam	157115-85-0	98%
T7108	Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to...
T15820	Mibampator	375345-95-2	97.63%
T15820	Mibampator (LY451395) is an effective and selective AMPA receptor potentiator.
T7355	IC87201	866927-10-8	97.44%
T7355	IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T10774	CFM-2	178616-26-7	97.16%
T10774	CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
T16801	(RS)-(Tetrazol-5-yl)glycine	138199-51-6	95.00%
T16801	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...
T4171	PEAQX	459836-30-7	100%
T4171	PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A...
T7706	LY-404187	211311-95-4	100%
T7706	LY404187 is a positive allosteric modulator of AMPA receptors
T10930	D-AP5	79055-68-8	100%
T10930	D-AP5 (D-APV) is a NMDA receptor antagonist.
T8435	YM90K	154164-30-4	100%
T8435	YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.