c-Kit

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene.KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as "steel factor" or "c-kit ligand".

Cat. No.	Product name	CAS No.	Purity
T1452	Axitinib	319460-85-0	99.53%
T1452	Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGF...
T5109	Avapritinib	1703793-34-3	99.5%
T5109	Avapritinib (BLU-285) is a dual inhibitor of the mutant KIT receptor (KIT D816V, IC50: 0.27 nM) and PDGFRα (PDGFRα D842V, IC50: 0.24 nM).
T1792L	Regorafenib monohydrate	1019206-88-2	99.47%
T1792L	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR...
T10651	C-Kit-IN-3	2363169-01-9	99.43%
T10651	c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).
T12145L	N-Desethylsunitinib hydrochloride	1261432-05-6	99.42%
T12145L	N-Desethylsunitinib hydrochloride is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ, and KIT inhibi...
T4191	Multi-kinase inhibitor 1	778274-97-8	99.34%
T4191	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.
T6097	GNF-5837	1033769-28-6	99.29%
T6097	GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
T2514	Linifanib	796967-16-3	99.29%
T2514	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDG...
T2070	Agerafenib	1188910-76-0	99.23%
T2070	Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.
T0093	Sorafenib tosylate	475207-59-1	99.2%
T0093	Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T6479	Dovitinib lactate hydrate	915769-50-5	99.17%
T6479	Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM,...
T8541	Lenvatinib mesylate	857890-39-2	99.03%
T8541	Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.
T10652	Vimseltinib	1628606-05-2	98.98%
T10652	Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).
T6166	Telatinib	332012-40-5	98.95%
T6166	Telatinib (Bay 57-9352) is an effective inhibitor of VEGFR2/3, c-Kit, and PDGFRα. The IC50s of Telatinib forVEGFR2/3, c-Kit and PDGFRα are 6 nM/4 nM, 1 nM, and 1...
T2288	Motesanib	453562-69-1	98.87%
T2288	Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits...
T1797	Cabozantinib S-malate	1140909-48-3	98.87%
T1797	Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with pot...
T11641	N-Desmethyl imatinib	404844-02-6	98.60%
T11641	N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T15199	Edicotinib	1142363-52-7	98.58%
T15199	Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effect...
T9689	M4205	2590556-80-0	98.52%
T9689	M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.
T2516	Amuvatinib	850879-09-3	98.48%
T2516	Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.