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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7102 BCTC 393514-24-4 98%
BCTC
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
T7189 AMG9810 545395-94-6 98%
AMG9810
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively)...
T6660 SB-705498 501951-42-4 98%
SB-705498
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
T6530 HC-030031 349085-38-7 98%
HC-030031
HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectiv...
T5962 TRPM8 antagonist WS-3 39711-79-0 98%
TRPM8 antagonist WS-3
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).
T5698 TRPM8 antagonist 2 259674-19-6 98%
TRPM8 antagonist 2
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.
T7191 Diphenyleneiodonium chloride 4673-26-1 98%
Diphenyleneiodonium chloride
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum...
T64337 PF-04745637 1917294-46-2 97.91%
PF-04745637
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
T1814 ICILIN 36945-98-9 97.61%
ICILIN
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
T1321 Nonivamide 2444-46-4 97.61%
Nonivamide
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Noni...
TQ0001 1,4-Cineole 470-67-7 97.15%
1,4-Cineole
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T77645 JC-229 97.14%
JC-229
JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).
T15465 HC-070 1628291-95-1 97.06%
HC-070
HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
T9776 TRPM4 inhibitor 8 1353979-43-7 97%
TRPM4 inhibitor 8
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
T6848 GSK1016790A 942206-85-1 96.25%
GSK1016790A
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial ce...
TN2429 Capsiate 205687-01-0 96.24%
Capsiate
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
T3865 Beta-Eudesmol 473-15-4 95.62%
beta-Eudesmol
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
T23106 Olvanil 58493-49-5 95.06%
Olvanil
Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.
T22124 Oleoyl Serotonin 1002100-44-8 100.00%
Oleoyl Serotonin
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.
T77723 RN-1665 1803003-65-7 100%
RN-1665
RN-1665 is a potent and selective TRPV4 receptor antagonist.
BCTC
T7102
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
AMG9810
T7189
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively)...
SB-705498
T6660
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
HC-030031
T6530
HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectiv...
TRPM8 antagonist WS-3
T5962
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).
TRPM8 antagonist 2
T5698
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.
Diphenyleneiodonium chloride
T7191
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum...
PF-04745637
T64337
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
ICILIN
T1814
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
Nonivamide
T1321
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Noni...
1,4-Cineole
TQ0001
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
JC-229
T77645
JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).
HC-070
T15465
HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
TRPM4 inhibitor 8
T9776
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
GSK1016790A
T6848
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial ce...
Capsiate
TN2429
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
beta-Eudesmol
T3865
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
Olvanil
T23106
Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.
Oleoyl Serotonin
T22124
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.
RN-1665
T77723
RN-1665 is a potent and selective TRPV4 receptor antagonist.
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TargetMol