TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat. No.	Product name	CAS No.	Purity
T24178	Isatoribine	122970-40-5	99.73%
T24178	Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.
TN1936	Mogroside III-E	88901-37-5	99.73%
TN1936	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
T15777	Loxoribine	121288-39-9	99.73%
T15777	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-t...
TQ0181	Resatorvid	243984-11-4	99.73%
TQ0181	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereb...
T5S0045	Isofraxidin	486-21-5	99.65%
T5S0045	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has...
T0194	Chloroquine phosphate	50-63-5	99.64%
T0194	Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of...
T38423	CL097	1026249-18-2	99.57%
T38423	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-st...
T2911	Stevioside	57817-89-7	99.52%
T2911	A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
T17032	Telratolimod	1359993-59-1	99.50%
T17032	Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.
T4080	Leonurine hydrochloride	24735-18-0	99.47%
T4080	Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor ...
T7672	MD2-TLR4-IN-1	2249801-12-3	99.46%
T7672	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
T4068	E6446 dihydrochloride	1345675-25-3	99.44%
T4068	E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
T4231	MD2-IN-1	111797-22-9	99.43%
T4231	MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).
T4206	E6446	1219925-73-1	99.41%
T4206	E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
TN2008	Okanin	484-76-4	99.4%
TN2008	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T80673	Chloranil	118-75-2	99.38%
T80673	Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflamm...
T9570	Enpatoran	2101938-42-3	99.38%
T9570	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
T8727	TH1020	1841460-82-9	99.37%
T8727	TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
T12933	SM-276001	473930-22-2	99.37%
T12933	SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T0134	Imiquimod	99011-02-6	99.31%
T0134	Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.