Serine Protease

Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes.

Cat. No.	Product name	CAS No.	Purity
T16501	PF-3644022	1276121-88-0	99.12%
T16501	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production...
T1145	Diminazene Aceturate	908-54-3	98.78%
T1145	Diminazene is a trypanocidal agent.
T6285	GSK-690693	937174-76-0	98.78%
T6285	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T13568L	BCX 1470 hydrochloride		98.76%
T13568L	BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor...
TN1022	Secologanoside	59472-23-0	98.69%
TN1022	Secologanoside shows anti-complementary, allelopathic, and anti-elastase activities.
T12613L	BAY-85-8501	1161921-82-9	98.63%
T12613L	BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)
T25549	JCP174	126062-19-9	98.19%
T25549	JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.
TN1372	Alpha-Amyrin	638-95-9	98.14%
TN1372	Alpha-Amyrin (alpha-Amyrine) is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepat...
T5597	ZT-12-037-01	2328073-61-4	98%
T5597	Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
T30519	BMS-363131	384829-65-6	97.82%
T30519	BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.
T2392	Nafamostat mesylate	82956-11-4	97.36%
T2392	Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and...
T3S0381	Chrysophanol 8-O-glucoside	13241-28-6	96.84%
T3S0381	Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose tr...
T3442	UK-371804	256477-09-5	95.81%
T3442	UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulc...
T9670L	Patamostat HCl	3031765-17-7	100%
T9670L	Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 ...
T3990	AA26-9	1312782-34-5	100%
T3990	AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
T8802	2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-	80499-32-7
T8802	2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine ...
T6564	Leupeptin Hemisulfate	103476-89-7	98%
T6564	Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the acti...
T13408	ZK824190	2254001-81-3	98%
T13408	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 16...
TP1792L	KKI-5 acetate(97145-43-2 free base)	TP1792L	98%
TP1792L	KKI-5 acetate is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as ...
T13257	Upamostat	590368-25-5	98%
T13257	Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.