STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

Cat. No.	Product name	CAS No.	Purity
T8655	SR-717	2375421-09-1	98.64%
T8655	SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes act...
T72482	Dazostinag disodium	2553413-93-5	98.59%
T72482	Dazostinag disodium (TAK-676) is a novel stimulator of interferon genes (STING) agonist and immune system modulator with antitumor activity that activates dendri...
T7081	CCCP	555-60-2	98.55%
T7081	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the ...
T6273	Vadimezan	117570-53-3	98.5%
T6273	Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and in...
T8798	MSA-2	129425-81-6	98.19%
T8798	MSA-2 is a potent and orally available non-nucleotide STING agonist.
T9029	STING-IN-3	2244881-69-2	98.15%
T9029	STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and ph...
T9137	SN-011	2249435-90-1	98.1%
T9137	SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a dem...
T7329	C-178	329198-87-0	98%
T7329	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
T9554	SN-008	2249106-01-0	96.83%
T9554	SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
T13015	STING agonist-4	2138300-40-8
T13015	STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
T13613	ChX710	2438721-44-7	98%
T13613	ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and...
T10252L2	ADU-S100 ammonium salt	1638750-96-5	98%
T10252L2	ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemi...
T9853	STING activator Compound 53	2259624-71-8	98%
T9853	STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised ...
T5516	DiABZI STING agonist-1 trihydrochloride	2138299-34-8	98%
T5516	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T11035	DiABZI STING agonist-1 (Tautomerism)	2138498-18-5	98%
T11035	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 13...
T8328	STING agonist-1	702662-50-8	98%
T8328	STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.