STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

Cat. No.	Product name	CAS No.	Purity
T79199	F-CRI1		98%
T79199	F-CRI1, a potent STING agonist with a dissociation constant (K d) of 40.62 nM, is an 18F-labeled radioactive probe employed for visualizing STING in the tumor mi...
T79313	BI 7446	2767011-00-5	98%
T79313	BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in...
T79320	Antitumor agent-114	2757762-91-5	98%
T79320	Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models,...
T79730	LB244		98%
T79730	LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependen...
T79779	SAP-04		98%
T79779	SAP-04 is a potent, orally active STING agonist exhibiting significant immunomodulatory effects appropriate for cancer therapy [1].
T81082	STING-IN-7	899947-07-0	98%
T81082	STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of ...
T82760	C-di-IMP disodium		98%
T82760	C-di-IMP disodium, a STING agonist, is utilized in tumor research [1].
T83047	Anti-inflammatory agent 65		98%
T83047	Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation ...
T75011	STING-IN-5	2920064-17-9	98%
T75011	STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO)...
T10065	2',3'-cGAMP	1441190-66-4	98%
T10065	2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3...
T5317	Cridanimod	38609-97-1	99.96%
T5317	Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
T36983	Cyclic-di-GMP disodium	2222132-40-1	99.93%
T36983	Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm fo...
T11035	DiABZI STING agonist-1 (Tautomerism)	2138498-18-5	99.72%
T11035	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 13...
T10065L	2',3'-cGAMP sodium	2734858-36-5	99.71%
T10065L	2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging...
T60000	STING (WT/R232) activity regulator 126	702662-64-4	99.61%
T60000	STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
T5674	H-151	941987-60-6	99.52%
T5674	H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING ...
T9204	SN-001	727699-84-5	99.51%
T9204	SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.
T5154	C-176	314054-00-7	99.40%
T5154	C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
T5516	DiABZI STING agonist-1 trihydrochloride	2138299-34-8	99.18%
T5516	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T74809	STING agonist-30	2951078-67-2	99.04%
T74809	STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a var...