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SARS-CoV

Severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1) is a strain of virus that causes severe acute respiratory syndrome (SARS). It is an enveloped, positive-sense, single-stranded RNA virus which infects the epithelial cells within the lungs. The virus enters the host cell by binding to the ACE2 receptor. It infects humans, bats, and palm civets.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79228 SARS-CoV-2-IN-50 98%
SARS-CoV-2-IN-50
SARS-CoV-2-IN-50 (Compound X77C) is a potent inhibitor of the SARS-CoV-2 main protease (M^pro), exhibiting high affinity for the enzyme's catalytic site [1].
T79234 RdRP-IN-7 98%
RdRP-IN-7
RdRP-IN-7, a RNA-dependent RNA polymerase (RdRp) inhibitor, demonstrates efficacy against SARS-CoV-2 infection with an inhibitory concentration (IC50) of 8.2 μM ...
T79243 SARS-CoV-2-IN-43 31356-11-3 98%
SARS-CoV-2-IN-43
Compound 8h, also known as SARS-CoV-2-IN-43, is a powerful inhibitor effective in obstructing the replication of SARS-CoV-2, exhibiting significant antiviral act...
T79244 SARS-CoV-2-IN-44 1311271-71-2 98%
SARS-CoV-2-IN-44
SARS-CoV-2-IN-44, an inhibitor of SARS-CoV-2, effectively suppresses viral replication with an EC50 value of 0.6μM and exhibits negligible cytotoxicity in Calu-3...
T79245 SARS-CoV-2-IN-45 98%
SARS-CoV-2-IN-45
SARS-CoV-2-IN-45 (Compound 8p) serves as an inhibitor of SARS-CoV-2, effectively hindering viral replication in Calu-3 cells with an EC50 value of 0.5 μM and exh...
T79278 SARS-CoV-2 Mpro-IN-7 98%
SARS-CoV-2 Mpro-IN-7
SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (CC50...
T79279 SARS-CoV-2 Mpro-IN-8 98%
SARS-CoV-2 Mpro-IN-8
SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1].
T79310 SARS-CoV-2-IN-53 98%
SARS-CoV-2-IN-53
ARS-CoV-2-IN-53 (Compd 5d) exhibits an inhibitory effect on SARS-CoV-2 replication, with an effective concentration (EC50) value of 14.3 μM, and demonstrates not...
T79328 SARS-CoV-2-IN-54 98%
SARS-CoV-2-IN-54
SARS-CoV-2-IN-54 (Compound 2), a SARS-CoV-2 inhibitor, exhibits antiviral activity by impeding the virus in Vero E6 cells with an inhibitory concentration (IC50)...
T79329 SARS-CoV-2-IN-56 98%
SARS-CoV-2-IN-56
SARS-CoV-2-IN-56 (Compound 63) is a SARS-CoV-2 inhibitor with antiviral activity, demonstrating inhibition of the virus in Vero E6 cells with an IC50 of 0.7 μM [...
T79339 NSC89641 98%
NSC89641
NSC89641 demonstrates potent inhibition of MERS-CoV M^pro, achieving an IC_50 value of less than 3.5 µM. Furthermore, it exerts significant inhibitory effects on...
T79344 CDD-1819 2894104-40-4 98%
CDD-1819
CDD-1819, a non-covalent and non-peptide compound, serves as a potent SARS-CoV-2 Mpro inhibitor, exhibiting a K i value of 5 nM. It also effectively inhibits the...
T79345 CDD-1733 2894104-33-5 98%
CDD-1733
CDD-1733 is a potent, non-covalent, and non-peptide inhibitor of the SARS-CoV-2 main protease (Mpro) with an inhibition constant (K i) of 12 nM. It effectively i...
T79346 CDD-1845 2894104-50-6 98%
CDD-1845
CDD-1845, a non-covalent, non-peptide inhibitor, exhibits potent inhibition of SARS-CoV-2 M^pro with a K_i value of 3 nM. Additionally, CDD-1845 is effective aga...
T79376 SARS-CoV-2 3CLpro-IN-19 98%
SARS-CoV-2 3CLpro-IN-19
SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of ...
T79414 SARS-CoV-2-IN-60 98%
SARS-CoV-2-IN-60
SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and e...
T79426 SARS-CoV-2-IN-61 98%
SARS-CoV-2-IN-61
SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 µM and demonstrating antiviral activities [1].
T79455 SARS-CoV-2 Mpro-IN-9 2754370-99-3 98%
SARS-CoV-2 Mpro-IN-9
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) ...
T79462 SARS-CoV-2 3CLpro-IN-14 98%
SARS-CoV-2 3CLpro-IN-14
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μ...
T79515 SARS-CoV-2 Mpro-IN-10 98%
SARS-CoV-2 Mpro-IN-10
SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in res...
SARS-CoV-2-IN-50
T79228
SARS-CoV-2-IN-50 (Compound X77C) is a potent inhibitor of the SARS-CoV-2 main protease (M^pro), exhibiting high affinity for the enzyme's catalytic site [1].
RdRP-IN-7
T79234
RdRP-IN-7, a RNA-dependent RNA polymerase (RdRp) inhibitor, demonstrates efficacy against SARS-CoV-2 infection with an inhibitory concentration (IC50) of 8.2 μM ...
SARS-CoV-2-IN-43
T79243
Compound 8h, also known as SARS-CoV-2-IN-43, is a powerful inhibitor effective in obstructing the replication of SARS-CoV-2, exhibiting significant antiviral act...
SARS-CoV-2-IN-44
T79244
SARS-CoV-2-IN-44, an inhibitor of SARS-CoV-2, effectively suppresses viral replication with an EC50 value of 0.6μM and exhibits negligible cytotoxicity in Calu-3...
SARS-CoV-2-IN-45
T79245
SARS-CoV-2-IN-45 (Compound 8p) serves as an inhibitor of SARS-CoV-2, effectively hindering viral replication in Calu-3 cells with an EC50 value of 0.5 μM and exh...
SARS-CoV-2 Mpro-IN-7
T79278
SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (CC50...
SARS-CoV-2 Mpro-IN-8
T79279
SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1].
SARS-CoV-2-IN-53
T79310
ARS-CoV-2-IN-53 (Compd 5d) exhibits an inhibitory effect on SARS-CoV-2 replication, with an effective concentration (EC50) value of 14.3 μM, and demonstrates not...
SARS-CoV-2-IN-54
T79328
SARS-CoV-2-IN-54 (Compound 2), a SARS-CoV-2 inhibitor, exhibits antiviral activity by impeding the virus in Vero E6 cells with an inhibitory concentration (IC50)...
SARS-CoV-2-IN-56
T79329
SARS-CoV-2-IN-56 (Compound 63) is a SARS-CoV-2 inhibitor with antiviral activity, demonstrating inhibition of the virus in Vero E6 cells with an IC50 of 0.7 μM [...
NSC89641
T79339
NSC89641 demonstrates potent inhibition of MERS-CoV M^pro, achieving an IC_50 value of less than 3.5 µM. Furthermore, it exerts significant inhibitory effects on...
CDD-1819
T79344
CDD-1819, a non-covalent and non-peptide compound, serves as a potent SARS-CoV-2 Mpro inhibitor, exhibiting a K i value of 5 nM. It also effectively inhibits the...
CDD-1733
T79345
CDD-1733 is a potent, non-covalent, and non-peptide inhibitor of the SARS-CoV-2 main protease (Mpro) with an inhibition constant (K i) of 12 nM. It effectively i...
CDD-1845
T79346
CDD-1845, a non-covalent, non-peptide inhibitor, exhibits potent inhibition of SARS-CoV-2 M^pro with a K_i value of 3 nM. Additionally, CDD-1845 is effective aga...
SARS-CoV-2 3CLpro-IN-19
T79376
SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of ...
SARS-CoV-2-IN-60
T79414
SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and e...
SARS-CoV-2-IN-61
T79426
SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 µM and demonstrating antiviral activities [1].
SARS-CoV-2 Mpro-IN-9
T79455
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) ...
SARS-CoV-2 3CLpro-IN-14
T79462
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μ...
SARS-CoV-2 Mpro-IN-10
T79515
SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in res...
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TargetMol