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Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T14865 Carboprost tromethamine 58551-69-2 99.61%
Carboprost tromethamine
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α and it can effectively promote law contraction of the uterus and significantly r...
T67946 EP2 receptor antagonist-2 615273-95-5 99.59%
EP2 receptor antagonist-2
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor . EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 rece...
T3S2007 MRE-269 475085-57-5 99.57%
MRE-269
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary art...
TMA0536 2-Acetylbenzoic acid 577-56-0 99.57%
2-Acetylbenzoic acid
2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potenc...
T2690 Tranilast 53902-12-8 99.57%
Tranilast
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of aller...
T21224 (+)-Fluprostenol 54276-17-4 99.56%
(+)-Fluprostenol
(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycop...
T7053 P-Hydroxycinnamic acid 7400-08-0 99.55%
p-Hydroxycinnamic acid
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prost...
T0212 Seratrodast 112665-43-7 99.54%
Seratrodast
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
T6399 AZD1981 802904-66-1 99.54%
AZD1981
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors,...
T1978 GW627368 439288-66-1 99.54%
GW627368
GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T11211 EP4 receptor antagonist 1 2287259-07-6 99.53%
EP4 receptor antagonist 1
EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 receptors...
T68155 Tebufelone 112018-00-5 99.52%
Tebufelone
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has...
TQ0292 Grapiprant 415903-37-6 99.49%
Grapiprant
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 n...
T24567 Octimibate 89838-96-0 99.49%
Octimibate
Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascu...
T2791 Pectolinarin 28978-02-1 99.47%
Pectolinarin
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
T3306 PF-04418948 1078166-57-0 99.45%
PF-04418948
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4,...
T15681 L-161982 147776-06-5 99.44%
L-161982
L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could...
T3889 Platycodin D 58479-68-8 99.43%
Platycodin D
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
TN1362 Afzelin 482-39-3 99.38%
Afzelin
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absor...
T62525 TP-16 2332972-26-4 99.33%
TP-16
TP-16 is a novel potent and selective EP4 antagonist that blocks the function of IMCs and enhances cytotoxic T cell-mediated tumor elimination in vivo.
Carboprost tromethamine
T14865
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α and it can effectively promote law contraction of the uterus and significantly r...
EP2 receptor antagonist-2
T67946
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor . EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 rece...
MRE-269
T3S2007
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary art...
2-Acetylbenzoic acid
TMA0536
2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potenc...
Tranilast
T2690
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of aller...
(+)-Fluprostenol
T21224
(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycop...
p-Hydroxycinnamic acid
T7053
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prost...
Seratrodast
T0212
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
AZD1981
T6399
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors,...
GW627368
T1978
GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
EP4 receptor antagonist 1
T11211
EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 receptors...
Tebufelone
T68155
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has...
Grapiprant
TQ0292
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 n...
Octimibate
T24567
Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascu...
Pectolinarin
T2791
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
PF-04418948
T3306
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4,...
L-161982
T15681
L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could...
Platycodin D
T3889
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
Afzelin
TN1362
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absor...
TP-16
T62525
TP-16 is a novel potent and selective EP4 antagonist that blocks the function of IMCs and enhances cytotoxic T cell-mediated tumor elimination in vivo.
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TargetMol