T9173 |
HM-30181 mesylate monohydrate
|
2097125-58-9
|
98.81%
|
|
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
|
T64133L |
Laniquidar TFA
|
|
98.74%
|
|
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavai...
|
T16026 |
MCI826
|
140646-80-6
|
98.73%
|
|
MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model of a...
|
T2S0271 |
Voacamine
|
3371-85-5
|
98.73%
|
|
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein ...
|
T28396 |
PGP-4008
|
365565-02-2
|
98.53%
|
|
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
|
T68124 |
Pafenolol
|
75949-61-0
|
98.43%
|
|
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
|
TN1757 |
Hypophyllanthin
|
33676-00-5
|
98.39%
|
|
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
|
T6287 |
Tariquidar
|
206873-63-4
|
98.34%
|
|
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
|
T2S2018 |
7beta-Hydroxylathyrol
|
34208-98-5
|
98%
|
|
7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties.
|
T2S0410 |
Euphorbia factor L1
|
76376-43-7
|
98%
|
|
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It ...
|
T3392 |
Sinapine thiocyanate
|
7431-77-8
|
98%
|
|
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
|
TJS1159 |
Chrysosplenetin
|
603-56-5
|
97.43%
|
|
Chrysosplenetin is a metabolic inhibitor of artemisinin.
|
T13383 |
Zamicastat
|
1080028-80-3
|
97.43%
|
|
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73....
|
TMA2270 |
Alisol F 24-acetate
|
443683-76-9
|
96.33%
|
|
Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX...
|
T30260 |
AZD-5672
|
780750-65-4
|
95.58%
|
|
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
|
T17216 |
Valspodar
|
121584-18-7
|
95%
|
|
Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.
|
TN4761 |
Phellamurin
|
52589-11-4
|
93.19%
|
|
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensur...
|
T0012 |
Cinchonine
|
118-10-5
|
86.31%
|
|
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting ...
|
T3002 |
Piperine
|
94-62-2
|
100%
|
|
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
|
T1222 |
Trifluoperazine dihydrochloride
|
440-17-5
|
100%
|
|
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
|