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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5701 OPHIOPOGONIN D 945619-74-9 98%
OPHIOPOGONIN D
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
T7535 RGX-202 353-09-3 98%
RGX-202
RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates...
T8505 SC-236 170569-86-5 98%
SC-236
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
T0646 5-Aminosalicylic Acid 89-57-6 97.88%
5-Aminosalicylic Acid
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is consid...
T12400 Peliglitazar racemate 331744-72-0 97.75%
Peliglitazar racemate
Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity agen...
T3709 XMD8-87 1234480-46-6 97.61%
XMD8-87
XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 trun...
T26986 Cevoglitazar 839673-52-8 97.39%
Cevoglitazar
Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.
T15567 Imiglitazar 250601-04-8 97.33%
Imiglitazar
Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.
T3S1701 Dihydrocurcumin 76474-56-1 97.23%
Dihydrocurcumin
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
T11825 LCB-2853 141335-10-6 97.15%
LCB-2853
LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.
T37974 (S)-Coriolic acid 29623-28-7 97.11%
(S)-Coriolic acid
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, ...
T3254 PHYTOL 150-86-7 96.80%
PHYTOL
PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activi...
T16739 RG-12525 120128-20-3 96.77%
RG-12525
RG-12525(NID 525) is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guine...
T50025 Lonazolac 53808-88-1 95.00%
Lonazolac
Lonazolac is a nonsteroidal anti-inflammatory drug[1].
T3090 Abietic Acid 514-10-3 92.6%
Abietic Acid
Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin.
T22596 BADGE 1675-54-3 85.3%
BADGE
PPARγ antagonist
T15440 GSK376501A 1010412-80-2 100%
GSK376501A
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
T6926 Palmitoylethanolamide 544-31-0 100%
Palmitoylethanolamide
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective ag...
T11339L Furegrelate 85666-24-6 100%
Furegrelate
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.
T7821 DG172 dihydrochloride 1361504-77-9 100%
DG172 dihydrochloride
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
OPHIOPOGONIN D
T5701
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
RGX-202
T7535
RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates...
SC-236
T8505
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
5-Aminosalicylic Acid
T0646
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is consid...
Peliglitazar racemate
T12400
Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity agen...
XMD8-87
T3709
XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 trun...
Cevoglitazar
T26986
Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.
Imiglitazar
T15567
Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.
Dihydrocurcumin
T3S1701
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
LCB-2853
T11825
LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.
(S)-Coriolic acid
T37974
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, ...
PHYTOL
T3254
PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activi...
RG-12525
T16739
RG-12525(NID 525) is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guine...
Lonazolac
T50025
Lonazolac is a nonsteroidal anti-inflammatory drug[1].
Abietic Acid
T3090
Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin.
BADGE
T22596
PPARγ antagonist
GSK376501A
T15440
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
Palmitoylethanolamide
T6926
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective ag...
Furegrelate
T11339L
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.
DG172 dihydrochloride
T7821
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
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TargetMol