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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5764 Alliin 556-27-4 99.62%
Alliin
Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induce...
T3867 Alpinetin 36052-37-6 99.61%
Alpinetin
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
T0705 Triflusal 322-79-2 99.61%
Triflusal
Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T60184 TUG-499 1206629-08-4 99.59%
TUG-499
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
T15581 Inolitazone 223132-37-4 99.58%
Inolitazone
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
T0214 Pioglitazone 111025-46-8 99.57%
Pioglitazone
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked...
TN3500 Beta-Amyrone 638-97-1 99.55%
beta-Amyrone
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through ...
T4408 Elafibranor 923978-27-2 99.55%
Elafibranor
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC...
T0212 Seratrodast 112665-43-7 99.54%
Seratrodast
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
T2413 FH535 108409-83-2 99.5%
FH535
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T15049 Daltroban 79094-20-5 99.49%
Daltroban
Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intrac...
T67933 BAY-4931 423150-91-8 99.47%
BAY-4931
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC 50 of 0.17 nM .
T23389 SR1664 1338259-05-4 99.43%
SR1664
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphoryl...
T0334 Rosiglitazone 122320-73-4 99.43%
Rosiglitazone
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidi...
T14176 Aleglitazar 475479-34-6 99.42%
Aleglitazar
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for ...
T67936 BAY-0069 420826-65-9 99.41%
BAY-0069
BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be u...
T12527L Mavodelpar free acid hydrochloride 99.39%
Mavodelpar free acid hydrochloride
Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.
T6926 Palmitoylethanolamide 544-31-0 99.38%
Palmitoylethanolamide
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective ag...
T9767 CC618 1680204-90-3 99.37%
CC618
CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.
T19500 Palmitelaidic Acid 10030-73-6 99.36%
Palmitelaidic Acid
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
Alliin
T5764
Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induce...
Alpinetin
T3867
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
Triflusal
T0705
Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
TUG-499
T60184
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
Inolitazone
T15581
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
Pioglitazone
T0214
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked...
beta-Amyrone
TN3500
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through ...
Elafibranor
T4408
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC...
Seratrodast
T0212
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
FH535
T2413
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
Daltroban
T15049
Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intrac...
BAY-4931
T67933
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC 50 of 0.17 nM .
SR1664
T23389
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphoryl...
Rosiglitazone
T0334
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidi...
Aleglitazar
T14176
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for ...
BAY-0069
T67936
BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be u...
Mavodelpar free acid hydrochloride
T12527L
Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.
Palmitoylethanolamide
T6926
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective ag...
CC618
T9767
CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.
Palmitelaidic Acid
T19500
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
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