PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
T13862	Recilisib	334969-03-8	99.84%
T13862	Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.
T2616	PIK-93	593960-11-3	99.83%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T4976	Umbralisib	1532533-67-7	99.83%
T4976	Umbralisib (TGR 1202) is a PI3Kδ inhibitor.
T3675	1-Deoxynojirimycin	19130-96-2	99.82%
T3675	1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
TQ0044	Seletalisib	1362850-20-1	99.81%
TQ0044	Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).
T2685	KU-55933	587871-26-9	99.80%
T2685	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T3348	PIK-293	900185-01-5	99.8%
T3348	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
T12831L	SAR405	1523406-39-4	99.79%
T12831L	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR...
T3985	GDC-0326	1282514-88-8	99.79%
T3985	GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).
T16567	PQR530	1927857-61-1	99.78%
T16567	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphor...
T15592	IPI-3063	1425043-73-7	99.77%
T15592	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
T9460	IMDK	881970-80-5	99.77%
T9460	iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits no...
T2008	LY294002	154447-36-6	99.76%
T2008	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC...
T6283	Wortmannin	19545-26-7	99.76%
T6283	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that bl...
T2798	Esculetin	305-01-1	99.76%
T2798	Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema,...
T2073	GSK2636771	1372540-25-4	99.74%
T2073	GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanc...
T6433	CAY10505	1218777-13-9	99.74%
T6433	CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).
T15375	Inavolisib	2060571-02-8	99.74%
T15375	Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. In...
T61618	PI3K-IN-38	1382979-64-7	99.74%
T61618	PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activ...
T1921	Alpelisib	1217486-61-7	99.73%
T1921	Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200...