PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
T7166	GNE-493	1033735-94-2	98%
T7166	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for ...
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine	55399-93-4	98%
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesit...
T6319	OSI-027	936890-98-1	98%
T6319	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTO...
T1961	Vistusertib	1009298-59-2	97.94%
T1961	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T24642	YH-306	1373764-75-0	97.87%
T24642	YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
T4867	Erucic acid	112-86-7	97.85%
T4867	Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Er...
T10804	CHMFL-PI3KD-317	2244992-76-3	97.8%
T10804	CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other clas...
T22377	NIBR-17	944396-88-7	97.67%
T22377	NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
T64392	PI3K-IN-46	304645-61-2	97.51%
T64392	PI3K-IN-46 is a specific inhibitor of PI3Kγ.
TMA2474	δ-Tocotrienol	25612-59-3	97.38%
TMA2474	δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
T16750	Rigosertib	592542-59-1	97.33%
T16750	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer a...
T3208	Brevianamide F	38136-70-8	97.30%
T3208	Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess i...
T1826	PI3K-IN-1	1349796-36-6	97.07%
T1826	PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T7015	Vps34-IN-1	1383716-33-3	97.04%
T7015	Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I...
T6630	Quercetin Dihydrate	6151-25-3	97.03%
T6630	Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine...
T3190	PIK-inhibitors	371934-59-7	96.98%
T3190	PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.
TN1405	Arnicolide D	34532-68-8	96.66%
TN1405	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T11593	I-OMe-Tyrphostin AG 538	1094048-77-7	96.66%
T11593	I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
T6072L	BGT226	915020-55-2	95.74%
T6072L	BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
T13140	Umbralisib R-enantiomer	1532533-69-9	95.61%
T13140	Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against...